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February 2010, Volume 87, Issue 2

  [Index by Author]  [Cover Caption]
Down Editorials
Down Pivotal Advance
Down Reviews
Down Cell Development, Differentiation, & Trafficking
Down Receptors, Signal Transduction, & Genes
Down Inflammation, Extracellular Mediators, & Effector Molecules
Down Host Defense & Pathophysiology
Down Translational & Clinical Immunology

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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF)
To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

EditorialsBack

Philippe Blancou and Ignacio Anegon
Editorial: Heme oxygenase-1 and dendritic cells: what else?
Accumulating evidence indicates that heme oxygenase-1 expression in dendritic cells could be the key step for providing immune suppression through Tregs in many diseases or disorders.
J Leukoc Biol 2010 87: 185–187 . [Full Text] [PDF]

Chris Hall and Phil Crosier
Editorial: Maintaining the balance—fishing for drugs to treat persistent neutrophilic inflammation
The use of zebrafish as a platform to acclerate the discovery of therapeutic drugs that promote the resolution of neutrophilic inflammation is discussed.
J Leukoc Biol 2010 87: 189–191 . [Full Text] [PDF]

Pivotal AdvanceBack

Markus Biburger, Gabi Theiner, Mirjam Schädle, Gerold Schuler, and Gisa Tiegs

HO-1 induction in human T cells inhibits their proliferation, HO-1 suppression in Tregs increases their proliferation, but neither treatment fundamentally changes their respective suppressive capacity.
J Leukoc Biol 2010 87: 193–202 . [Abstract] [Full Text] [PDF]

Catherine A. Loynes, Jane S. Martin, Anne Robertson, Daniel M. I. Trushell, Philip W. Ingham, Moira K. B. Whyte, and Stephen A. Renshaw

The resolution of neutrophilic inflammation in the zebrafish can be visualized in vivo and manipulated by a range of pharmacological mediators, demonstrating a role for neutrophil apoptosis in this process.
J Leukoc Biol 2010 87: 203–212 . [Abstract] [Full Text] [PDF] [Supplemental Movies and Legends]

ReviewsBack

Lauren O. Bakaletz

The synergistic relationship between URT viruses and bacteria in OM pathogenesis is not fully understood, but overall is predicated on viral impairment of airway defenses.
J Leukoc Biol 2010 87: 213–222 . [Abstract] [Full Text] [PDF]

M. L. del Rio, C. L. Lucas, L. Buhler, G. Rayat, and J. I. Rodriguez-Barbosa

This review highlights how the blockade of the co-stimulatory HVEM/LIGHT interaction or agonist signaling through the inhibitory BTLA and CD160 receptors could contribute to the control of deleterious immune responses.
J Leukoc Biol 2010 87: 223–235 . [Abstract] [Full Text] [PDF]

Sabine Hoves, Joseph A. Trapani, and Ilia Voskoboinik

The review discusses the controversies in the field of cytotoxic lymphocyte secretory granule death pathways.
J Leukoc Biol 2010 87: 237–243 . [Abstract] [Full Text] [PDF]

Cell Development, Differentiation, & TraffickingBack

Semra J. Kirk, Jacqueline M. Cliff, J. Alero Thomas, and Theresa H. Ward

In differentiating B cells, proliferation of endoplasmic reticulum appears as tightly clustered juxtanuclear spherical structures which expand to fill the cytosol without synchronizing to cell expansion.
J Leukoc Biol 2010 87: 245–255 . [Abstract] [Full Text] [PDF] [Supplemental Figures 1-4 Movie 1 Table 1]

Qingsheng Li, Cheryl Eppolito, Kunle Odunsi, and Protul A. Shrikant

The molecular basis of collaboration between instructions that program CD8+ T cells for long-term responses.
J Leukoc Biol 2010 87: 257–263 . [Abstract] [Full Text] [PDF]

Anis Larbi, Henning Zelba, David Goldeck, and Graham Pawelec

T cell differentiation and functions are altered at low oxygen, possibly via HIF-1{alpha} and glycolysis up-regulation.
J Leukoc Biol 2010 87: 265–273 . [Abstract] [Full Text] [PDF] [Supplemental Figures 1-4]

Receptors, Signal Transduction, & GenesBack

Leah E. Cole, Michelle H. W. Laird, Anna Seekatz, Araceli Santiago, Zhaozhao Jiang, Eileen Barry, Kari Ann Shirey, Katherine A. Fitzgerald, and Stefanie N. Vogel

Enhanced or prolonged interaction between an agonist and TLR2 can overcome the need for TIRAP.
J Leukoc Biol 2010 87: 275–281 . [Abstract] [Full Text] [PDF]

Lieke C. J. van den Berk, Bastiaan J. H. Jansen, Kim G. C. Siebers-Vermeulen, Helene Roelofs, Carl G. Figdor, Gosse J. Adema, and Ruurd Torensma

The TNF promoter is silenced in mesenchymal stem cells able to respond to LPS by NF{kappa}B translocation and cytokine production yet without TNF.
J Leukoc Biol 2010 87: 283–289 . [Abstract] [Full Text] [PDF] [Supplemental Figures 1 and 2]

Susan S. Ishmael and Donald W. MacGlashan, Jr.

The critical signaling kinase of IgE-mediated reactions, syk, can be down-regulated in maturing basophils by chronic ag-gregation without altering their expression of FcRI, granule staining, and histamine content.
J Leukoc Biol 2010 87: 291–300 . [Abstract] [Full Text] [PDF]

Inflammation, Extracellular Mediators, & Effector MoleculesBack

Jeremy S. Schaefer, Dina Montufar-Solis, Nadarajah Vigneswaran, and John R. Klein

IL-23 and IL-10 have opposing effects on IL-17 synthesis by mouse ICOS+ T cells in the colonic epithelium.
J Leukoc Biol 2010 87: 301–308 . [Abstract] [Full Text] [PDF]

Concetta Crisafulli, Rosanna Di Paola, Emanuela Mazzon, Irene Paterniti, Maria Galuppo, Tiziana Genovese, Placido Bramanti, Alessandro Cappellani, and Salvatore Cuzzocrea

T0901317, LXR receptor agonist, reduces the inflammatory response and the ileum injury associated to splanchnic artery occlusion shock.
J Leukoc Biol 2010 87: 309–321 . [Abstract] [Full Text] [PDF]

Maria Fernanda de Souza Costa, Raquel de Souza-Martins, Mariana C. de Souza, Cláudia F. Benjamim, Bruno Piva, Bruno L. Diaz, Marc Peters-Golden, Maria das Graças Henriques, Cláudio Canetti, and Carmen Penido

{gamma}{delta} T cell migration into mouse pleural cavities during inflammatory responses triggered by LPS, Mycobacterium bovis BCG, or ovalbumin depends on leukotriene B4 and BLT1 receptor.
J Leukoc Biol 2010 87: 323–332 . [Abstract] [Full Text] [PDF]

Host Defense & PathophysiologyBack

Stanley C. Henry, Maria Traver, Xiaojou Daniell, Maanasa Indaram, Tim Oliver, and Gregory A. Taylor

Irgm1 controls macrophage motility by regulating the positioning of specific GKS IRG proteins to the plasma membrane, leading to altered Rac activity and actin remodelling.
J Leukoc Biol 2010 87: 333–343 . [Abstract] [Full Text] [PDF] [Supplemental Figure 1, Movies 1 and 2, Movie Legends]

Translational & Clinical ImmunologyBack

Courtney M. Lappas, Po-Ching Liu, Joel Linden, Elizabeth M. Kang, and Harry L. Malech

The selective activation of the A2A has therapeutic potential in both the prevention and treatment of acute GVHD.
J Leukoc Biol 2010 87: 345–354 . [Abstract] [Full Text] [PDF]

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.