Other Issues:	Contents: July 2009, Volume 86, Issue 1   [Index by Author]  [Cover Caption] Editorials Pivotal Advance Reviews Spotlight on Leading Edge Research Cell Development, Differentiation, & Trafficking Receptors, Signal Transduction, & Genes Inflammation, Extracellular Mediators, & Effector Molecules Host Defense & Pathophysiology
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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF)

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Editorials

Maryna V. Skok Editorial: To channel or not to channel? Functioning of nicotinic acetylcholine receptors in leukocytes J Leukoc Biol 2009 86: 1–3 . [Full Text] [PDF]

Alison Crawford and E. John Wherry Editorial: Therapeutic potential of targeting BTLA J Leukoc Biol 2009 86: 5–8 . [Full Text] [PDF]

Ajit Lalvani and Suzanne Hingley-Wilson Editorial: Live or let die—does HIV exacerbate tuberculosis by attenuating M. tuberculosis-induced apoptosis? J Leukoc Biol 2009 86: 9–11 . [Full Text] [PDF]

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Pivotal Advance

Andreas Hecker, Zbigniew Mikulski, Katrin S. Lips, Uwe Pfeil, Anna Zakrzewicz, Sigrid Wilker, Petra Hartmann, Winfried Padberg, Ignaz Wessler, Wolfgang Kummer, and Veronika Grau Pivotal Advance: Up-regulation of acetylcholine synthesis and paracrine cholinergic signaling in intravascular transplant leukocytes during rejection of rat renal allografts A new role and source of the old mediator acetylcholine is described, which is produced by graft monocytes and attenuates monocytic ATP-signaling. J Leukoc Biol 2009 86: 13–22 . [Abstract] [Full Text] [PDF]

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Reviews

Mingcai Li, Xiaojin Liu, Yanchun Zhou, and Shao Bo Su Interferon-s: the modulators of antivirus, antitumor, and immune responses Recent findings concerning the biology of IFN-s and their pathophysiological roles in viral infection, cancer, and immune responses of the innate and adaptive arms are summarized. J Leukoc Biol 2009 86: 23–32 . [Abstract] [Full Text] [PDF]

Dong-Yeop Chang and Eui-Cheol Shin Immune-based therapy for chronic hepatitis C Development of novel therapies for chronic hepatitis C by modulating innate and adaptive immune responses are reviewed. J Leukoc Biol 2009 86: 33–39 . [Abstract] [Full Text] [PDF]

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Spotlight on Leading Edge Research

Wayne Truong, Wayne W. Hancock, Jennifer C. Plester, Shaheed Merani, David C. Rayner, Govindarajan Thangavelu, Kenneth M. Murphy, Colin C. Anderson, and A. M. James Shapiro BTLA targeting modulates lymphocyte phenotype, function, and numbers and attenuates disease in nonobese diabetic mice Targeting coinhibitory T cell receptors using monoclonal antibodies attenuates autoimmune diabetes by altering lymphocyte number and function. J Leukoc Biol 2009 86: 41–51 . [Abstract] [Full Text] [PDF]

Naimish R. Patel, Katharine Swan, Xin Li, Souvenir D. Tachado, and Henry Koziel Impaired M. tuberculosis-mediated apoptosis in alveolar macrophages from HIV+ persons: potential role of IL-10 and BCL-3 HIV alters the lung environment through increased IL-10, leading to an impaired macrophage apoptotic response to Mycobacterium tuberculosis via upregulation of macrophage BCL-3. J Leukoc Biol 2009 86: 53–60 . [Abstract] [Full Text] [PDF]

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Cell Development, Differentiation, & Trafficking

Annegret Reinhold, Sibylle Reimann, Dirk Reinhold, Burkhart Schraven, and Mauro Togni Expression of SKAP-HOM in DCs is required for an optimal immune response in vivo The genetic deletion of SKAP-HOM, an ubiquitously expressed cytosolic adapter protein, affected DC:T cell interactions reducing immune response. J Leukoc Biol 2009 86: 61–71 . [Abstract] [Full Text] [PDF]

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Receptors, Signal Transduction, & Genes

Adil Anwar, Amy K. Keating, David Joung, Susan Sather, Grace K. Kim, Kelly K. Sawczyn, Luis Brandão, Peter M. Henson, and Douglas K. Graham Mer tyrosine kinase (MerTK) promotes macrophage survival following exposure to oxidative stress Macrophages treated with hydrogen peroxide exhibit increased Mer-dependent signaling resulting in enhanced cellular survival in an oxidative stress environment. J Leukoc Biol 2009 86: 73–79 . [Abstract] [Full Text] [PDF]

Reza Chakour, Cindy Allenbach, Florian Desgranges, Mélanie Charmoy, Jacques Mauel, Irène Garcia, Pascal Launois, Jacques Louis, and Fabienne Tacchini-Cottier A new function of the Fas-FasL pathway in macrophage activation Triggering of the Fas/Fas ligand pathway leads to macrophage activation and to the induction of microbicidal activity in macrophages infected with Leishmania major. J Leukoc Biol 2009 86: 81–90 . [Abstract] [Full Text] [PDF]

Sebastian Seth, Anna-Maria Georgoudaki, Benedict J. Chambers, Quan Qiu, Elisabeth Kremmer, Michael K. Maier, Niklas Czeloth, Inga Ravens, Reinhold Foerster, and Günter Bernhardt Heterogeneous expression of the adhesion receptor CD226 on murine NK and T cells and its function in NK-mediated killing of immature dendritic cells Newly generated monoclonal antibodies directed against murine CD226 define CD226/CD155-interaction in NK-mediated killing of immature dendritic cells. J Leukoc Biol 2009 86: 91–101 . [Abstract] [Full Text] [PDF]

Hervé Benoist, Raphaël Culerrier, Guillaume Poiroux, Bruno Ségui, Alain Jauneau, Els J. M. Van Damme, Willy J. Peumans, Annick Barre, and Pierre Rougé Two structurally identical mannose-specific jacalin-related lectins display different effects on human T lymphocyte activation and cell death Subtle changes in cell surface N-glycan recognition can modulate the T lymphocyte fate. J Leukoc Biol 2009 86: 103–114 . [Abstract] [Full Text] [PDF]

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Inflammation, Extracellular Mediators, & Effector Molecules

Laura Piqueras, Maria Jesus Sanz, Mauro Perretti, Esteban Morcillo, Lucy Norling, Jane A. Mitchell, Yoyo Li, and David Bishop-Bailey Activation of PPARβ/ inhibits leukocyte recruitment, cell adhesion molecule expression, and chemokine release Activation of the nuclear receptor PPARb/d inhibits acute inflammatory responses in vitro with human primary cells and in vivo by targeting the endothelial cell-leukocyte interaction. J Leukoc Biol 2009 86: 115–122 . [Abstract] [Full Text] [PDF]

Virginia Maina, Alessia Cotena, Andrea Doni, Manuela Nebuloni, Fabio Pasqualini, Caroline M. Milner, Anthony J. Day, Alberto Mantovani, and Cecilia Garlanda Coregulation in human leukocytes of the long pentraxin PTX3 and TSG-6 Coordinated expression of TSG-6 and PTX3 in myelomonocytic cells and MDDC support the hypothesis that these two proteins may have a role in extracellular matrix remodeling at sites of inflammation. J Leukoc Biol 2009 86: 123–132 . [Abstract] [Full Text] [PDF]

Donald L. Evans, Meghan A. Connor, Lauren D. Moss, Sarah Lackay, John H. Leary, III, Thomas Krunkosky, and Liliana Jaso-Friedmann Cellular expression and antimicrobial function of a phylogenetically conserved novel histone 1x-like protein on mouse cells: a potential new class of pattern recognition receptor A novel bifunctional histone 1X-like protein is a soluble antimicrobial and a membrane pattern recognition receptor. J Leukoc Biol 2009 86: 133–141 . [Abstract] [Full Text] [PDF]

Regina Tavano, Susanna Franzoso, Paola Cecchini, Elena Cartocci, Francesca Oriente, Beatrice Aricò, and Emanuele Papini The membrane expression of Neisseria meningitidis adhesin A (NadA) increases the proimmune effects of MenB OMVs on human macrophages, compared with NadA– OMVs, without further stimulating their proinflammatory activity on circulating monocytes Anti-Meningococcus B vaccine candidate stimulates macrophages. J Leukoc Biol 2009 86: 143–153 . [Abstract] [Full Text] [PDF]

Nadine Koch, Mechthild Jung, Robert Sabat, Jörn Krätzschmar, Wolf-Dietrich Döcke, Khusru Asadullah, Hans-Dieter Volk, and Gerald Grütz IL-10 protects monocytes and macrophages from complement-mediated lysis A new function for IL-10 is shown which might enable IL-10-programmed macrophages to survive longer in hostile inflammatory environment. J Leukoc Biol 2009 86: 155–166 . [Abstract] [Full Text] [PDF]

Toshio Inoue, Yoshihiro Suzuki, Tetsuro Yoshimaru, and Chisei Ra Ca2+-dependent mast cell death induced by Ag (I) via cardiolipin oxidation and ATP depletion Ag (I) induction leads to a unique necrotic death pathway in which Ca2+-dependent cardiolipin oxidation and ATP depletion play critical roles. J Leukoc Biol 2009 86: 167–179 . [Abstract] [Full Text] [PDF]

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Host Defense & Pathophysiology

Johnah C. Galicia, Manjunatha R. Benakanakere, Panagiota G. Stathopoulou, and Denis F. Kinane Neutrophils rescue gingival epithelial cells from bacterial-induced apoptosis During mucosal infection, neutrophils prevent epithelial cell apoptosis by phagocytosing bacteria prior to undergoing apoptosis themselves. J Leukoc Biol 2009 86: 181–186 . [Abstract] [Full Text] [PDF]

Ce Tang, Hisakata Yamada, Kensuke Shibata, Shin-ichi Yoshida, Worawidh Wajjwalku, and Yasunobu Yoshikai IL-15 protects antigen-specific CD8+ T cell contraction after Mycobacterium bovis bacillus Calmette-Guérin infection In vivo administration of IL-15 at the contraction phase in BCG infection inhibited apoptosis of effector CD8+ T cells resulting in the significant increase of Ag-specific memory CD8+ T cells. J Leukoc Biol 2009 86: 187–194 . [Abstract] [Full Text] [PDF]

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.