In their article in this issue, Tharp et al investigate the gradient parameters and signalling mechanisms that induce robust migration of neutrophils away from a peak concentration of chemokine, termed chemorepulsion or fugetaxis. The cover figure shows the paths of primary neutrophils undergoing chemokinesis (yellow), chemoattraction (blue), or chemorepulsion (red) in stable linear, Interleukin-8 gradients in microfluidic devices; upper left: no stimulus, upper right: 0 to 120 nM IL-8 gradient, lower left: 0 to 1.2 µM IL-8 gradient, lower right: 0.6 to 1.2 µM IL-8 gradient. For more information, see pages 539-554.