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A more recent version of this article appeared on July 1, 2009

Published online before print April 30, 2009
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© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.1208761

Received for publication December 22, 2008.
Revised February 12, 2009.
Accepted for publication March 1, 2009.

Article

Interferon-{lambda}s: the modulators of antivirus, antitumor, and immune responses

Mingcai Li , Xiaojin Liu , Yanchun Zhou , and Shao Bo Su @

Institute of Inflammation and Immune Diseases, Shantou University Medical College, Shantou, China

@ To whom correspondence should be addressed. E-mail: shaobosu{at}yahoo.com.


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Abstract

IFN-{lambda}s, including IFN-{lambda}1, IFN-{lambda}2, and IFN-{lambda}3, also known as IL-29, IL-28A, or IL-28B, are a newly described group of cytokines distantly related to the type I IFNs and IL-10 family members. The IFN-{lambda}R complex consists of a unique ligand-binding chain, IFN-{lambda}R1 (also designated IL-28R{alpha}), and an accessory chain, IL-10R2, which is shared with receptors for IL-10-related cytokines. IFN-{lambda}s signal through the IFN-{lambda}R and activate pathways of JAK-STATs and MAPKs to induce antiviral, antiproliferative, antitumor, and immune responses. In this review, we summarize recent findings about the biology of IFN-{lambda}s and their pathophysiological roles in viral infection, cancer, and immune responses of the innate and adaptive arms.

Key Words: IFN-{lambda} • IL-28 • IL-29 • immunoregulation