Journal of Leukocyte Biology
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© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.1105640

Received for publication November 8, 2005.
Revised December 12, 2005.
Accepted for publication December 23, 2005.

Article

Sex-specific phenotypical and functional differences in peripheral human V{gamma}9/V{delta}2 T cells

Nadia Caccamo *, Francesco Dieli *, Daniela Wesch {dagger}, Hassan Jomaa {ddagger}, and Matthias Eberl {ddagger}@

*Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, Italy; {dagger}Institut für Immunologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Germany; and {ddagger}Biochemisches Institut, Infektiologie, Justus-Liebig-Universität Giessen, Germany

@ To whom correspondence should be addressed. E-mail: meberl{at}izb.unibe.ch.


  Abstract

V{gamma}9/V{delta}2 T cells constitute a minor proportion of human peripheral blood T cells that can expand rapidly upon infection with microbial pathogens. V{gamma}9/V{delta}2 T cell numbers change characteristically with age, rising from birth to puberty and gradually decreasing again beyond 30 years of age. In adults, female blood donors have significantly higher levels than males, implying that circulating V{gamma}9/V{delta}2 T cells in women remain elevated for a longer period in life and drop less strikingly than in men. This loss in men is accompanied by a substantial depletion of CD27-CD45RA- and CD27-CD45RA+ effector T cells and a parallel increase in CD27+CD45RA- central memory T cells, and in women, the distribution of V{gamma}9/V{delta}2 T cell subsets remains virtually unchanged. The phenotypical conversion in men older than 30 years is mirrored by an increased proliferative response of V{gamma}9/V{delta}2 T cells and a reduced interferon-{gamma} secretion upon stimulation with isopentenyl pyrophosphate in vitro.

Key Words: {gamma}{delta} T lymphocytes • memory subsets • male immune system • gender-related bias • aging • IPP




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