Journal of Leukocyte Biology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on June 1, 2006

Published online before print March 10, 2006
This Article
Right arrow Full Text (Reprint (PDF))
Right arrow All Versions of this Article:
jlb.1105625v1
79/6/1093    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kin, N. W.
Right arrow Articles by Sanders, V. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kin, N. W.
Right arrow Articles by Sanders, V. M.
© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.1105625

Received for publication November 2, 2005.
Revised January 13, 2006.
Accepted for publication January 17, 2006.

Article

It takes nerve to tell T and B cells what to do

Nicholas W. Kin and Virginia M. Sanders @

Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus

@ To whom correspondence should be addressed. E-mail: Sanders.302{at}osu.edu.


  Abstract

The existence of an association between the brain and immunity has been documented. Data show that the nervous and immune systems communicate with one another to maintain immune homeostasis. Activated immune cells secrete cytokines that influence central nervous system activity, which in turn, activates output through the peripheral nervous system to regulate the level of immune cell activity and the subsequent magnitude of an immune response. In this review, we will focus our presentation and discussion on the findings that indicate a regulatory role for the peripheral sympathetic nervous system in modulating the level of cytokine and antibody produced during an immune response. Data will be discussed from studies involving the stimulation of the {beta}2 adrenergic receptor expressed on CD4+ T cells and B cells by norepinephrine or selective agonists. We will also discuss how dysregulation of this line of communication between the nervous and immune systems might contribute to disease development and progression.

Key Words: adrenergic receptor • sympathetic nervous system • norepinephrine • CD4+ T cell • Th1 cell • Th2 cell




This article has been cited by other articles:


Home page
 BloodHome page
M. Cosentino, A. M. Fietta, M. Ferrari, E. Rasini, R. Bombelli, E. Carcano, F. Saporiti, F. Meloni, F. Marino, and S. Lecchini
Human CD4+CD25+ regulatory T cells selectively express tyrosine hydroxylase and contain endogenous catecholamines subserving an autocrine/paracrine inhibitory functional loop
Blood, January 15, 2007; 109(2): 632 - 642.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2006 by the Society for Leukocyte Biology.