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Published online before print March 2, 2004

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© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.1103586

Received for publication November 24, 2003.
Revised January 22, 2004.
Accepted for publication January 28, 2004.

Article

The generation of T cell memory: a review describing the molecular and cellular events following OX40 (CD134) engagement

Andrew D. Weinberg ^*@, Dean E. Evans ^*, Colin Thalhofer ^*, Tom Shi ^*, and Rodney A. Prell

*Earle A. Chiles Research Institute, Robert W. Franz Cancer Research Center, Providence Portland Medical Center, Oregon; and Cell Genesys, Foster City, California

	Abstract

OX40 (CD134), a membrane-bound member of the tumor necrosis factor-receptor superfamily, is expressed primarily on activated CD4⁺ T cells. Following engagement on the cell surface, OX40 delivers a costimulatory signal that leads to potent, proinflammatory effects. Engagement of OX40 during antigen (Ag)-specific stimulation of T cells leads to increased production of memory T cells, increased migration of Ag-specific T cells, enhanced cytokine production by effector T cells, and the ability to break peripheral T cell tolerance in vivo. Therefore, OX40 engagement in vivo could have important ramifications for the enhancement of vaccine strategies and inhibition of unwanted inflammation. This review summarizes the molecular and cellular events that occur following OX40 engagement during Ag-specific T cell activation.

Key Words: TNF-R • antigen-specific T cells

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