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Published online before print December 6, 2007

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© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.0907609

Received for publication September 7, 2007.
Revised October 25, 2007.
Accepted for publication October 26, 2007.

Article

The inhibitory collagen receptor LAIR-1 (CD305)

Department of Immunology, University Medical Center Utrecht, The Netherlands

^@ To whom correspondence should be addressed. E-mail: l.meyaard{at}azu.nl.

	Abstract

The immune system protects the body from invaders such as viruses and bacteria. Immune cells must be activated in the correct context to function properly. It is critical that the receptors, costimulatory molecules, and cytokines that orchestrate this activation are carefully regulated to prevent uncontrolled inflammation and autoimmunity. Inhibitory receptors play an important role in regulation of immune cell function, usually upon interaction with ligands present on other cells. In contrast, the function of the inhibitory leukocyte-associated Ig-like receptor (LAIR)-1 can be regulated by extracellular matrix collagens. LAIR-1 is expressed on most cells of the immune system, and its function has been studied on multiple cell types. This review summarizes current literature about LAIR-1, a receptor that potentially is able to regulate multiple steps of an immune response.

Key Words: extracellular matrix • ITIM • ITAM