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© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.0808474

Received for publication August 9, 2008.
Revised September 17, 2008.
Accepted for publication September 19, 2008.

Article

Leukocyte trafficking in primary immunodeficiencies

Luigi D. Notarangelo *@ and Raffaele Badolato {dagger}

*Division of Immunology, Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA; and {dagger}Department of Pediatrics, University of Brescia, Brescia, Italy

@ To whom correspondence should be addressed. E-mail: luigi.notarangelo{at}childrens.harvard.edu.


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Abstract

Leukocyte recirculation through central and peripheral lymphoid organs and peripheral tissues is essential to maintain immune homeostasis. Some of the genetically determined, primary immunodeficiencies compromise leukocyte trafficking. Here, we review the mechanisms and consequences of impaired leukocyte trafficking in leukocyte adhesion-deficiency syndromes, Warts-Hypo-{gamma}-globulinemia-Infections-Myelokathexis syndrome and Wiskott-Aldrich syndrome.

Key Words: adhesion deficiency • WHIM syndrome • Wiskott-Aldrich syndrome




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