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Published online before print November 29, 2006

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© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.0806510

Received for publication August 9, 2006.
Revised October 18, 2006.
Accepted for publication October 25, 2006.

Article

The CD14+ CD16+ blood monocytes: their role in infection and inflammation

Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom, and Clinical Cooperation Group, Inflammatory Lung Disease, GSF and Asklepios-Kliniken, Gauting, Germany

^@ To whom correspondence should be addressed. E-mail: LZH1{at}le.ac.uk.

	Abstract

Blood monocyte subpopulations have been defined in man initially, and the two major types of monocytes are the CD14++ CD16- and the CD14+ CD16+ monocytes. These cells have been shown to exhibit distinct phenotype and function, and the CD14+ CD16+ were labeled proinflammatory based on higher expression of proinflammatory cytokines and higher potency in antigen presentation. The current review describes these properties, including the relationship to dendritic cells, and summarizes the host of publications about CD14+ CD16+ monocytes in inflammation and infectious disease in man, all of which suggest a crucial role of these cells in the disease processes. The review also covers the more recent description of homologues of these cells in other model species, which is expected to better define the role of monocyte subsets in disease.

Key Words: cytokines • migration • HIV • arthritis • atherosclerosis

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