| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
Published online before print October 5, 2004
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Article |
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor
@ To whom correspondence should be addressed. E-mail: jswan{at}umich.edu.
 |
Abstract |
|---|
Phagocytosis by macrophages can be initiated by Fc
receptors (FcR) in membranes that bind to Fc regions of immunoglobulin G (IgG). Activated FcR transduce signals to cytoplasm, which regulate the internalization of IgG-coated particles into plasma membrane-derived vacuoles, phagosomes. Particles internalized by phagocytosis are much larger than FcR, which prompts questions of if and how the receptors are coordinated with each other. FcR-mediated signal transduction entails recruitment of proteins from cytoplasm to the receptor, largely via protein phosphorylation. These FcR signaling complexes then activate proteins that regulate actin, myosin, membrane fusion, and the production of reactive oxygen intermediates. Recent fluorescence microscopic studies of phagocytosis in macrophages indicate that signaling by FcR occurs as a sequence of distinct stages, evident in the spatial and temporal patterns of phosphoinositides, protein kinase C, and Rho-family GTPase activation on forming phagosomes. The coordination of these stages may be regulated by lipids or lipid-anchored proteins, which diffuse away from FcR complexes. Lateral diffusion of FcR-derived signals could integrate FcR-dependent responses over large areas of membrane in the forming phagosome.
Key Words: macrophage • actin • PI-3 kinase • Rac • Cdc42
This article has been cited by other articles:
|
|
 |
|
  P. V. Beum, D. A. Mack, A. W. Pawluczkowycz, M. A. Lindorfer, and R. P. Taylor Binding of Rituximab, Trastuzumab, Cetuximab, or mAb T101 to Cancer Cells Promotes Trogocytosis Mediated by THP-1 Cells and Monocytes J. Immunol., December 1, 2008; 181(11): 8120 - 8132. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Charles, M. B. Humphrey, X. Zhao, E. Quarles, M. C. Nakamura, A. Aderem, W. E. Seaman, and K. D. Smith The Innate Immune Response to Salmonella enterica Serovar Typhimurium by Macrophages Is Dependent on TREM2-DAP12 Infect. Immun., June 1, 2008; 76(6): 2439 - 2447. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Haberzettl, R. P. F. Schins, D. Hohr, V. Wilhelmi, P. J. A. Borm, and C. Albrecht Impact of the Fc{gamma}II-receptor on quartz uptake and inflammatory response by alveolar macrophages Am J Physiol Lung Cell Mol Physiol, June 1, 2008; 294(6): L1137 - L1148. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Zaru, P. Mollahan, and C. Watts 3-Phosphoinositide-dependent Kinase 1 Deficiency Perturbs Toll-like Receptor Signaling Events and Actin Cytoskeleton Dynamics in Dendritic Cells J. Biol. Chem., January 11, 2008; 283(2): 929 - 939. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Canetti, C. H. Serezani, R. G. Atrasz, E. S. White, D. M. Aronoff, and M. Peters-Golden Activation of Phosphatase and Tensin Homolog on Chromosome 10 Mediates the Inhibition of Fc{gamma}R Phagocytosis by Prostaglandin E2 in Alveolar Macrophages J. Immunol., December 15, 2007; 179(12): 8350 - 8356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Herrmann, J. Bernardo, H. J. Long, K. Seetoo, M. E. McMenamin, E. L. Batista Jr., T. E. Van Dyke, and E. R. Simons Sequential Chemotactic and Phagocytic Activation of Human Polymorphonuclear Neutrophils Infect. Immun., August 1, 2007; 75(8): 3989 - 3998. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Jay, E. Skokos, F. Laiwalla, M.-M. Krady, and T. R. Kyriakides Foreign Body Giant Cell Formation Is Preceded by Lamellipodia Formation and Can Be Attenuated by Inhibition of Rac1 Activation Am. J. Pathol., August 1, 2007; 171(2): 632 - 640. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Kamen, J. Levinsohn, and J. A. Swanson Differential Association of Phosphatidylinositol 3-Kinase, SHIP-1, and PTEN with Forming Phagosomes Mol. Biol. Cell, July 1, 2007; 18(7): 2463 - 2472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. N. Tu, H.-Y. Jeong, H.-Y. Kwon, A. D. Ogunniyi, J. C. Paton, S.-N. Pyo, and D.-K. Rhee Modulation of Adherence, Invasion, and Tumor Necrosis Factor Alpha Secretion during the Early Stages of Infection by Streptococcus pneumoniae ClpL Infect. Immun., June 1, 2007; 75(6): 2996 - 3005. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Rueda, O. Gaide, L. Ho, E. Lewkowicz, F. Niedergang, S. Hailfinger, F. Rebeaud, M. Guzzardi, B. Conne, M. Thelen, et al. Bcl10 Controls TCR- and Fc{gamma}R-Induced Actin Polymerization J. Immunol., April 1, 2007; 178(7): 4373 - 4384. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Garcia-Garcia, E. J. Brown, and C. Rosales Transmembrane Mutations to Fc{gamma}RIIA Alter Its Association with Lipid Rafts: Implications for Receptor Signaling J. Immunol., March 1, 2007; 178(5): 3048 - 3058. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Barrionuevo, M. Beigier-Bompadre, J. M. Ilarregui, M. A. Toscano, G. A. Bianco, M. A. Isturiz, and G. A. Rabinovich A Novel Function for Galectin-1 at the Crossroad of Innate and Adaptive Immunity: Galectin-1 Regulates Monocyte/Macrophage Physiology through a Nonapoptotic ERK-Dependent Pathway J. Immunol., January 1, 2007; 178(1): 436 - 445. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Hatsuzawa, T. Tamura, H. Hashimoto, H. Hashimoto, S. Yokoya, M. Miura, H. Nagaya, and I. Wada Involvement of Syntaxin 18, an Endoplasmic Reticulum (ER)-localized SNARE Protein, in ER-mediated Phagocytosis Mol. Biol. Cell, September 1, 2006; 17(9): 3964 - 3977. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Seth, C. Otomo, and M. K. Rosen Autoinhibition regulates cellular localization and actin assembly activity of the diaphanous-related formins FRL{alpha} and mDia1 J. Cell Biol., August 28, 2006; 174(5): 701 - 713. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-I. Suh, N. D. Stull, X. J. Li, W. Tian, M. O. Price, S. Grinstein, M. B. Yaffe, S. Atkinson, and M. C. Dinauer The phosphoinositide-binding protein p40phox activates the NADPH oxidase during Fc{gamma}IIA receptor-induced phagocytosis J. Exp. Med., August 7, 2006; 203(8): 1915 - 1925. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Herant, V. Heinrich, and M. Dembo Mechanics of neutrophil phagocytosis: experiments and quantitative models. J. Cell Sci., May 1, 2006; 119(Pt 9): 1903 - 1913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. H. Schuurhuis, N. van Montfoort, A. Ioan-Facsinay, R. Jiawan, M. Camps, J. Nouta, C. J. M. Melief, J. S. Verbeek, and F. Ossendorp Immune complex-loaded dendritic cells are superior to soluble immune complexes as antitumor vaccine. J. Immunol., April 15, 2006; 176(8): 4573 - 4580. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Sokac and W. M. Bement Kiss-and-Coat and Compartment Mixing: Coupling Exocytosis to Signal Generation and Local Actin Assembly Mol. Biol. Cell, April 1, 2006; 17(4): 1495 - 1502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Neal, C. Leaphart, R. Levy, J. Prince, T. R. Billiar, S. Watkins, J. Li, S. Cetin, H. Ford, A. Schreiber, et al. Enterocyte TLR4 Mediates Phagocytosis and Translocation of Bacteria Across the Intestinal Barrier. J. Immunol., March 1, 2006; 176(5): 3070 - 3079. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Mock, M. Vakevainen, K. Deng, J. L. Latimer, J. A. Young, N. S. C. van Oers, S. Greenberg, and E. J. Hansen Haemophilus ducreyi Targets Src Family Protein Tyrosine Kinases To Inhibit Phagocytic Signaling Infect. Immun., December 1, 2005; 73(12): 7808 - 7816. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Smalley, N. Signoret, D. Robertson, A. Tilley, A. Hann, K. Ewan, Y. Ding, H. Paterson, and T. C. Dale Dishevelled (Dvl-2) activates canonical Wnt signalling in the absence of cytoplasmic puncta J. Cell Sci., November 15, 2005; 118(22): 5279 - 5289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sobota, A. Strzelecka-Kiliszek, E. Gladkowska, K. Yoshida, K. Mrozinska, and K. Kwiatkowska Binding of IgG-Opsonized Particles to Fc{gamma}R Is an Active Stage of Phagocytosis That Involves Receptor Clustering and Phosphorylation J. Immunol., October 1, 2005; 175(7): 4450 - 4457. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Underhill, E. Rossnagle, C. A. Lowell, and R. M. Simmons Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production Blood, October 1, 2005; 106(7): 2543 - 2550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Yoneda, H. A.B. Multhaupt, and J. R. Couchman The Rho kinases I and II regulate different aspects of myosin II activity J. Cell Biol., August 1, 2005; 170(3): 443 - 453. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
