Journal of Leukocyte Biology Myeloid cells, immune suppression, tumor immunology
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A more recent version of this article appeared on February 1, 2005

Published online before print November 17, 2004
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© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.0704399

Received for publication July 14, 2004.

Accepted for publication October 26, 2004.

Article

Reduction in CD1d expression on dendritic cells and macrophages by an acute virus infection

Yinling Lin , Tonya J. Roberts , Philip M. Spence , and Randy R. Brutkiewicz @

Department of Microbiology and Immunology, Indiana University School of Medicine, The Walther Oncology Center, and The Walther Cancer Institute, Indianapolis

@ To whom correspondence should be addressed. E-mail: rbrutkie{at}iupui.edu.


  Abstract

Mice were infected with lymphocytic choriomeningitis virus (LCMV) to determine if changes in CD1d expression occurred during an acute virus infection. It is interesting that a decrease in CD1d expression on splenic dendritic cells (DC) and macrophages (M{Phi}) was observed for at least 3 months post-LCMV infection, and vaccinia virus and vesicular stomatitis virus induced similar changes in CD1d upon infection with those viruses. The reduction of CD1d cell-surface expression on DC and M{Phi} was independent of interferon-{gamma} and interleukin-12 expression but partially recovered in transporter associated with antigen processing-1-deficient mice, suggesting that CD8+ T cells may play a role. Thus, one consequence of the induction of a cellular immune response is a change in CD1d expression, which may constitute a key element in regulating antiviral immunity.

Key Words: innate immunity • spleen • peripheral organs • antigen presenting cells




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