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Published online before print December 28, 2006

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© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.0606383

Received for publication June 8, 2006.
Revised October 18, 2006.
Accepted for publication October 25, 2006.

Article

An eye’s view of T regulatory cells

Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA

^@ To whom correspondence should be addressed. E-mail: joan.stein{at}schepens.harvard.edu.

	Abstract

T regulatory (Treg) cells have been studied for more than 30 years. Recently, changing technology and attitudes have led to new interest in T cell regulation of the immune responses. The eye is an immune-privileged site with unique mechanisms for the prevention of damaging immune inflammation. The eye fashions its Treg cells in novel ways to prevent immune inflammation locally and systemically. The purpose of this mini-review is to condense and summarize reports of Treg cells dependent on the eye in the context of the Treg literature in general.

Key Words: immune regulation • TGF- • ACAID