Published online before print October 2, 2003
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Article |
: an overview of signals, mechanisms, and functions
,
,,@
*Institute for Molecular Bioscience, University of Queensland, St. Lucia, Brisbane, Australia; CRC for Chronic Inflammatory Diseases, Parkville, Victoria, Australia; and Molecular Genetics Group, Institute of Reproduction and Development, Monash Medical Centre, Monash University, Clayton, Victoria, Australia
@ To whom correspondence should be addressed. E-mail: D.Hume{at}imb.uq.edu.au.
Interferon-
(IFN-) coordinates a diverse array of cellular programs through transcriptional regulation of immunologically relevant genes. This article reviews the current understanding of IFN- ligand, receptor, signal transduction, and cellular effects with a focus on macrophage responses and to a lesser extent, responses from nonmacrophage cell types that influence macrophage function during infection. The current model for IFN- signal transduction is discussed, as well as signal regulation and factors conferring signal specificity. Cellular effects of IFN- are described, including up-regulation of pathogen recognition, antigen processing, and presentation, the antiviral state, inhibition of cellular proliferation, and effects on apoptosis, activation of microbicidal effector functions, immunomodulation, and leukocyte trafficking. In addition, integration of signaling and response with other cytokines and pathogen-associated molecular patterns, such as tumor necrosis factor-
, interleukin-4, type I IFNs, and lipopolysaccharide, are discussed.
Key Words: macrophage • cytokine • lipopolysaccharide • Toll-like receptor • inflammation
This article has been cited by other articles:
 |
|
 |
|
  R. B. Pyles, G. E. Jezek, and T. D. Eaves-Pyles Toll-Like Receptor 3 Agonist Protection against Experimental Francisella tularensis Respiratory Tract Infection Infect. Immun., April 1, 2010; 78(4): 1700 - 1710. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. P. Senft, R. H. Taylor, W. Lei, S. A. Campbell, J. L. Tipper, M. J. Martinez, T. L. Witt, C. C. Clay, and K. S. Harrod Respiratory Syncytial Virus Impairs Macrophage IFN-{alpha}/{beta}- and IFN-{gamma}-Stimulated Transcription by Distinct Mechanisms Am. J. Respir. Cell Mol. Biol., April 1, 2010; 42(4): 404 - 414. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Mazumder, X. Li, and S. Barik Translation Control: A Multifaceted Regulator of Inflammatory Response J. Immunol., April 1, 2010; 184(7): 3311 - 3319. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Zhou, Y. He, X. Zhang, J. Xu, Y. Luo, Y. Wang, S. G. Franzblau, Z. Yang, R. J. Chan, Y. Liu, et al. Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents PNAS, March 9, 2010; 107(10): 4573 - 4578. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Boulet, R. Song, P. Kamya, J. Bruneau, N. H. Shoukry, C. M. Tsoukas, and N. F. Bernard HIV Protective KIR3DL1 and HLA-B Genotypes Influence NK Cell Function Following Stimulation with HLA-Devoid Cells J. Immunol., February 15, 2010; 184(4): 2057 - 2064. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. K. Gregg, L. Nichols, Y. Chen, B. Lu, and V. H. Engelhard Mechanisms of Spatial and Temporal Development of Autoimmune Vitiligo in Tyrosinase-Specific TCR Transgenic Mice J. Immunol., February 15, 2010; 184(4): 1909 - 1917. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. N. Wolfe, A. T. Karanikas, S. E. Hester, M. J. Kennett, and E. T. Harvill IL-10 Induction by Bordetella parapertussis Limits a Protective IFN-{gamma} Response J. Immunol., February 1, 2010; 184(3): 1392 - 1400. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. G. Jansen, T. H. van Kuppevelt, W. F. Daamen, A. M. Kuijpers-Jagtman, and J. W. Von den Hoff Interferon-{gamma}-loaded collagen scaffolds reduce myofibroblast numbers in rat palatal mucosa Eur J Orthod, January 27, 2010; (2010): cjp129v1 - cjp129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Warawa, D. Long, R. Rosenke, D. Gardner, and F. C. Gherardini Role for the Burkholderia pseudomallei Capsular Polysaccharide Encoded by the wcb Operon in Acute Disseminated Melioidosis Infect. Immun., December 1, 2009; 77(12): 5252 - 5261. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Peng, J. Zhu, A. Klock, K. Phasouk, M.-L. Huang, D. M. Koelle, A. Wald, and L. Corey Evasion of the Mucosal Innate Immune System by Herpes Simplex Virus Type 2 J. Virol., December 1, 2009; 83(23): 12559 - 12568. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Barber, A. Rynda, and C. L. Sentman Chimeric NKG2D Expressing T Cells Eliminate Immunosuppression and Activate Immunity within the Ovarian Tumor Microenvironment J. Immunol., December 1, 2009; 183(11): 6939 - 6947. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. George, N. L. Banik, and S. K. Ray Combination of hTERT Knockdown and IFN-{gamma} Treatment Inhibited Angiogenesis and Tumor Progression in Glioblastoma Clin. Cancer Res., December 1, 2009; 15(23): 7186 - 7195. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Costigan, A. Moss, A. Latremoliere, C. Johnston, M. Verma-Gandhu, T. A. Herbert, L. Barrett, G. J. Brenner, D. Vardeh, C. J. Woolf, et al. T-Cell Infiltration and Signaling in the Adult Dorsal Spinal Cord Is a Major Contributor to Neuropathic Pain-Like Hypersensitivity J. Neurosci., November 18, 2009; 29(46): 14415 - 14422. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. V. Bowers, J. J. Horvath, J. E. Bond, G. J. Cianciolo, and S. V. Pizzo Antigen delivery by {alpha}2-macroglobulin enhances the cytotoxic T lymphocyte response J. Leukoc. Biol., November 1, 2009; 86(5): 1259 - 1268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Gueguinou, C. Huin-Schohn, M. Bascove, J.-L. Bueb, E. Tschirhart, C. Legrand-Frossi, and J.-P. Frippiat Could spaceflight-associated immune system weakening preclude the expansion of human presence beyond Earth's orbit? J. Leukoc. Biol., November 1, 2009; 86(5): 1027 - 1038. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. C. Patel, K. H. Fisher, E. C. C. Yang, C. M. Deane, and R. E. Harrison Proteomic Analysis of Microtubule-associated Proteins during Macrophage Activation Mol. Cell. Proteomics, November 1, 2009; 8(11): 2500 - 2514. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. MULLER-HUBENTHAL, M. AZEMAR, D. LORENZEN, M. HUBER, M. A FREUDENBERG, C. GALANOS, C. UNGER, and B. HILDENBRAND Tumour Biology: Tumour-associated Inflammation versus Antitumor Immunity Anticancer Res, November 1, 2009; 29(11): 4795 - 4805. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Dodig and R. Zrinski-Topic Serial Interferon Gamma Release Assay in Latent Tuberculosis Infection Lab Med, November 1, 2009; 40(11): 681 - 682. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Nijnik, J. Pistolic, A. Wyatt, S. Tam, and R. E. W. Hancock Human Cathelicidin Peptide LL-37 Modulates the Effects of IFN-{gamma} on APCs J. Immunol., November 1, 2009; 183(9): 5788 - 5798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Yu, M. Wei, H. Mao, J. Zhang, T. Hughes, T. Mitsui, I.-k. Park, C. Hwang, S. Liu, G. Marcucci, et al. CD94 Defines Phenotypically and Functionally Distinct Mouse NK Cell Subsets J. Immunol., October 15, 2009; 183(8): 4968 - 4974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Poovassery, D. Sarr, G. Smith, T. Nagy, and J. M. Moore Malaria-Induced Murine Pregnancy Failure: Distinct Roles for IFN-{gamma} and TNF J. Immunol., October 15, 2009; 183(8): 5342 - 5349. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Cao, A. Guo, Z. Liu, Y. Tan, G. Wu, C. Zhang, Y. Zhao, and H. Chen Investigation of New Dominant-Negative Inhibitors of Anthrax Protective Antigen Mutants for Use in Therapy and Vaccination Infect. Immun., October 1, 2009; 77(10): 4679 - 4687. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Masic, J. S. Booth, G. K. Mutwiri, L. A. Babiuk, and Y. Zhou Elastase-Dependent Live Attenuated Swine Influenza A Viruses Are Immunogenic and Confer Protection against Swine Influenza A Virus Infection in Pigs J. Virol., October 1, 2009; 83(19): 10198 - 10210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Starr, M. Fuchsberger, L. S. Lau, A. P. Uldrich, A. Goradia, T. A. Willson, A. M. Verhagen, W. S. Alexander, and M. J. Smyth SOCS-1 Binding to Tyrosine 441 of IFN-{gamma} Receptor Subunit 1 Contributes to the Attenuation of IFN-{gamma} Signaling In Vivo J. Immunol., October 1, 2009; 183(7): 4537 - 4544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Nussbaum, S. Ben-Adi, T. Genzler, M. Sela, and G. Rosen Involvement of Toll-Like Receptors 2 and 4 in the Innate Immune Response to Treponema denticola and Its Outer Sheath Components Infect. Immun., September 1, 2009; 77(9): 3939 - 3947. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Gerber, B. Yatsula, C. L. Maier, T. J. Sadler, L. W. Whittaker, and J. S. Pober Interferon-Gamma Induces Prolyl Hydroxylase (PHD)3 Through a STAT1-Dependent Mechanism in Human Endothelial Cells Arterioscler Thromb Vasc Biol, September 1, 2009; 29(9): 1363 - 1369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Haedicke, C. Brown, and M. H. Naghavi The brain-specific factor FEZ1 is a determinant of neuronal susceptibility to HIV-1 infection PNAS, August 18, 2009; 106(33): 14040 - 14045. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Shaykhiev, A. Krause, J. Salit, Y. Strulovici-Barel, B.-G. Harvey, T. P. O'Connor, and R. G. Crystal Smoking-Dependent Reprogramming of Alveolar Macrophage Polarization: Implication for Pathogenesis of Chronic Obstructive Pulmonary Disease J. Immunol., August 15, 2009; 183(4): 2867 - 2883. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-C. Tsai, J.-I. Kai, W.-C. Huang, C.-Y. Wang, Y. Wang, C.-L. Chen, Y.-T. Fang, Y.-S. Lin, R. Anderson, S.-H. Chen, et al. Glycogen Synthase Kinase-3{beta} Facilitates IFN-{gamma}-Induced STAT1 Activation by Regulating Src Homology-2 Domain-Containing Phosphatase 2 J. Immunol., July 15, 2009; 183(2): 856 - 864. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. He, L. Wu, H. K. Kim, H. Li, C. A. Elmets, and H. Xu IL-17 and IFN-{gamma} Mediate the Elicitation of Contact Hypersensitivity Responses by Different Mechanisms and Both Are Required for Optimal Responses J. Immunol., July 15, 2009; 183(2): 1463 - 1470. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. S. Liu, J. Leerberg, K. MacDonald, G. R. Leggatt, and I. H. Frazer IFN-{gamma} Promotes Generation of IL-10 Secreting CD4+ T Cells that Suppress Generation of CD8 Responses in an Antigen-Experienced Host J. Immunol., July 1, 2009; 183(1): 51 - 58. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. M. Cathcart, M. A. Fields, M. Zheng, B. Marshall, and S. S. Atherton Infiltrating Cells and IFN{gamma} Production in the Injected Eye after Uniocular Anterior Chamber Inoculation of HSV-1 Invest. Ophthalmol. Vis. Sci., May 1, 2009; 50(5): 2269 - 2275. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Malur, A. J. Mccoy, S. Arce, B. P. Barna, M. S. Kavuru, A. G. Malur, and M. J. Thomassen Deletion of PPAR{gamma} in Alveolar Macrophages Is Associated with a Th-1 Pulmonary Inflammatory Response J. Immunol., May 1, 2009; 182(9): 5816 - 5822. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. Ogilvie, J. R. SternJohn, B. Rattenbacher, I. A. Vlasova, D. A. Williams, H. H. Hau, P. J. Blackshear, and P. R. Bohjanen Tristetraprolin Mediates Interferon-{gamma} mRNA Decay J. Biol. Chem., April 24, 2009; 284(17): 11216 - 11223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Park, M. A. Hughes, M. Burdick, R. M. Strieter, and B. Mehrad Early NK Cell-Derived IFN-{gamma} Is Essential to Host Defense in Neutropenic Invasive Aspergillosis J. Immunol., April 1, 2009; 182(7): 4306 - 4312. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. D. Bannerman Pathogen-dependent induction of cytokines and other soluble inflammatory mediators during intramammary infection of dairy cows J Anim Sci, April 1, 2009; 87(13_suppl): 10 - 25. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Lopez-Munoz, F. J. Roca, J. Meseguer, and V. Mulero New Insights into the Evolution of IFNs: Zebrafish Group II IFNs Induce a Rapid and Transient Expression of IFN-Dependent Genes and Display Powerful Antiviral Activities J. Immunol., March 15, 2009; 182(6): 3440 - 3449. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Olson Jr., T. C. Bates, H. Izadi, J. D. Radolf, S. A. Huber, J. E. Boyson, and J. Anguita Local Production of IFN-{gamma} by Invariant NKT Cells Modulates Acute Lyme Carditis J. Immunol., March 15, 2009; 182(6): 3728 - 3734. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Li, M. VanRoey, C. Wang, T.-h. T. Chen, A. Korman, and K. Jooss Anti-Programmed Death-1 Synergizes with Granulocyte Macrophage Colony-Stimulating Factor-Secreting Tumor Cell Immunotherapy Providing Therapeutic Benefit to Mice with Established Tumors Clin. Cancer Res., March 1, 2009; 15(5): 1623 - 1634. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Sattler, U. Wagner, M. Rossol, J. Sieper, P. Wu, A. Krause, W. A. Schmidt, S. Radmer, S. Kohler, C. Romagnani, et al. Cytokine-induced human IFN-{gamma}-secreting effector-memory Th cells in chronic autoimmune inflammation Blood, February 26, 2009; 113(9): 1948 - 1956. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Yang, H. Li, P. W. Chen, H. Alizadeh, Y. He, R. N. Hogan, and J. Y. Niederkorn PD-L1 Expression on Human Ocular Cells and Its Possible Role in Regulating Immune-Mediated Ocular Inflammation Invest. Ophthalmol. Vis. Sci., January 1, 2009; 50(1): 273 - 280. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Gridley, J. M. Slater, X. Luo-Owen, A. Rizvi, S. K. Chapes, L. S. Stodieck, V. L. Ferguson, and M. J. Pecaut Spaceflight effects on T lymphocyte distribution, function and gene expression J Appl Physiol, January 1, 2009; 106(1): 194 - 202. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Nakamura, Y. Komagiri, T. Kojo, and M. Kubokawa Delayed and acute effects of interferon-{gamma} on activity of an inwardly rectifying K+ channel in cultured human proximal tubule cells Am J Physiol Renal Physiol, January 1, 2009; 296(1): F46 - F53. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Negishi, T. Osawa, K. Ogami, X. Ouyang, S. Sakaguchi, R. Koshiba, H. Yanai, Y. Seko, H. Shitara, K. Bishop, et al. A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity PNAS, December 23, 2008; 105(51): 20446 - 20451. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Miller, Y. Ma, J. Bian, K. C. F. Sheehan, J. F. Zachary, J. H. Weis, R. D. Schreiber, and J. J. Weis A Critical Role for Type I IFN in Arthritis Development following Borrelia burgdorferi Infection of Mice J. Immunol., December 15, 2008; 181(12): 8492 - 8503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Shi, M. Sakuma, T. Mooroka, A. Liscoe, H. Gao, K. J. Croce, A. Sharma, D. Kaplan, D. R. Greaves, Y. Wang, et al. Down-regulation of the forkhead transcription factor Foxp1 is required for monocyte differentiation and macrophage function Blood, December 1, 2008; 112(12): 4699 - 4711. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Hume Macrophages as APC and the Dendritic Cell Myth J. Immunol., November 1, 2008; 181(9): 5829 - 5835. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. De Lerma Barbaro, A. De Ambrosis, B. Banelli, G. L. Pira, O. Aresu, M. Romani, S. Ferrini, and R. S. Accolla Methylation of CIITA promoter IV causes loss of HLA-II inducibility by IFN-{gamma} in promyelocytic cells Int. Immunol., November 1, 2008; 20(11): 1457 - 1466. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Baron and J.-L. Davignon Inhibition of IFN-{gamma}-Induced STAT1 Tyrosine Phosphorylation by Human CMV Is Mediated by SHP2 J. Immunol., October 15, 2008; 181(8): 5530 - 5536. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Wu and S. N. Meydani Age-associated changes in immune and inflammatory responses: impact of vitamin E intervention J. Leukoc. Biol., October 1, 2008; 84(4): 900 - 914. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. De Pascalis, B. C. Taylor, and K. L. Elkins Diverse Myeloid and Lymphoid Cell Subpopulations Produce Gamma Interferon during Early Innate Immune Responses to Francisella tularensis Live Vaccine Strain Infect. Immun., September 1, 2008; 76(9): 4311 - 4321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Cosseau, D. A. Devine, E. Dullaghan, J. L. Gardy, A. Chikatamarla, S. Gellatly, L. L. Yu, J. Pistolic, R. Falsafi, J. Tagg, et al. The Commensal Streptococcus salivarius K12 Downregulates the Innate Immune Responses of Human Epithelial Cells and Promotes Host-Microbe Homeostasis Infect. Immun., September 1, 2008; 76(9): 4163 - 4175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-S. Delisle, L. Gaboury, M.-P. Belanger, E. Tasse, H. Yagita, and C. Perreault Graft-versus-host disease causes failure of donor hematopoiesis and lymphopoiesis in interferon-{gamma} receptor-deficient hosts Blood, September 1, 2008; 112(5): 2111 - 2119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. B. Wilson, M. Ray, M. Lutz, D. Sharda, J. Xu, and P. A. Hankey The RON Receptor Tyrosine Kinase Regulates IFN-{gamma} Production and Responses in Innate Immunity J. Immunol., August 15, 2008; 181(4): 2303 - 2310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Opiela, R. B. Levy, and B. Adkins Murine neonates develop vigorous in vivo cytotoxic and Th1/Th2 responses upon exposure to low doses of NIMA-like alloantigens Blood, August 15, 2008; 112(4): 1530 - 1538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Beurel and R. S. Jope Differential Regulation of STAT Family Members by Glycogen Synthase Kinase-3 J. Biol. Chem., August 8, 2008; 283(32): 21934 - 21944. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. V. Kravchenko, G. F. Kaufmann, J. C. Mathison, D. A. Scott, A. Z. Katz, D. C. Grauer, M. Lehmann, M. M. Meijler, K. D. Janda, and R. J. Ulevitch Modulation of Gene Expression via Disruption of NF-{kappa}B Signaling by a Bacterial Small Molecule Science, July 11, 2008; 321(5886): 259 - 263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Kintscher, M. Hartge, K. Hess, A. Foryst-Ludwig, M. Clemenz, M. Wabitsch, P. Fischer-Posovszky, T. F.E. Barth, D. Dragun, T. Skurk, et al. T-lymphocyte Infiltration in Visceral Adipose Tissue: A Primary Event in Adipose Tissue Inflammation and the Development of Obesity-Mediated Insulin Resistance Arterioscler Thromb Vasc Biol, July 1, 2008; 28(7): 1304 - 1310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Strowig, F. Brilot, and C. Munz Noncytotoxic Functions of NK Cells: Direct Pathogen Restriction and Assistance to Adaptive Immunity J. Immunol., June 15, 2008; 180(12): 7785 - 7791. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Hu, X. Hu, L. Boumsell, and L. B. Ivashkiv IFN-{gamma} and STAT1 Arrest Monocyte Migration and Modulate RAC/CDC42 Pathways J. Immunol., June 15, 2008; 180(12): 8057 - 8065. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Sexton and A. C. Harrison Susceptibility to nontuberculous mycobacterial lung disease Eur. Respir. J., June 1, 2008; 31(6): 1322 - 1333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Rupper and J. A. Cardelli Induction of Guanylate Binding Protein 5 by Gamma Interferon Increases Susceptibility to Salmonella enterica Serovar Typhimurium-Induced Pyroptosis in RAW 264.7 Cells Infect. Immun., June 1, 2008; 76(6): 2304 - 2315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. Shao, R. Suresh, V. Vakil, R. H. Gomer, and D. Pilling Pivotal Advance: Th-1 cytokines inhibit, and Th-2 cytokines promote fibrocyte differentiation J. Leukoc. Biol., June 1, 2008; 83(6): 1323 - 1333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Lembo, M. Pelletier, R. Iyer, M. Timko, J. C. Dudda, T. E. West, C. B. Wilson, A. M. Hajjar, and S. J. Skerrett Administration of a Synthetic TLR4 Agonist Protects Mice from Pneumonic Tularemia J. Immunol., June 1, 2008; 180(11): 7574 - 7581. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Tebow, D. L. Sherrill, I. C. Lohman, D. A. Stern, A. L. Wright, F. D. Martinez, M. Halonen, and S. Guerra Effects of Parental Smoking on Interferon {gamma} Production in Children Pediatrics, June 1, 2008; 121(6): e1563 - e1569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Liang and B. Roizman Expression of Gamma Interferon-Dependent Genes Is Blocked Independently by Virion Host Shutoff RNase and by US3 Protein Kinase J. Virol., May 15, 2008; 82(10): 4688 - 4696. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Feld, V. M. Shpacovitch, C. Ehrhardt, C. Kerkhoff, M. D. Hollenberg, N. Vergnolle, S. Ludwig, and M. Steinhoff Agonists of Proteinase-Activated Receptor-2 Enhance IFN-{gamma}-Inducible Effects on Human Monocytes: Role in Influenza A Infection J. Immunol., May 15, 2008; 180(10): 6903 - 6910. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Miu, N. H. Hunt, and H. J. Ball Predominance of Interferon-Related Responses in the Brain during Murine Malaria, as Identified by Microarray Analysis Infect. Immun., May 1, 2008; 76(5): 1812 - 1824. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Page, D. Chaudhary, S. J. Goldman, and M. T. Kasaian Natural killer cells from protein kinase C {theta}-/- mice stimulated with interleukin-12 are deficient in production of interferon-{gamma} J. Leukoc. Biol., May 1, 2008; 83(5): 1267 - 1276. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D. Kalliolias and L. B. Ivashkiv IL-27 Activates Human Monocytes via STAT1 and Suppresses IL-10 Production but the Inflammatory Functions of IL-27 Are Abrogated by TLRs and p38 J. Immunol., May 1, 2008; 180(9): 6325 - 6333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Jutras, M. Houde, N. Currier, J. Boulais, S. Duclos, S. LaBoissiere, E. Bonneil, P. Kearney, P. Thibault, E. Paramithiotis, et al. Modulation of the Phagosome Proteome by Interferon-{gamma} Mol. Cell. Proteomics, April 1, 2008; 7(4): 697 - 715. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. M. Iovine, S. Pursnani, A. Voldman, G. Wasserman, M. J. Blaser, and Y. Weinrauch Reactive Nitrogen Species Contribute to Innate Host Defense against Campylobacter jejuni Infect. Immun., March 1, 2008; 76(3): 986 - 993. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Rosenberger, A. E. Clark, P. M. Treuting, C. D. Johnson, and A. Aderem ATF3 regulates MCMV infection in mice by modulating IFN-{gamma} expression in natural killer cells PNAS, February 19, 2008; 105(7): 2544 - 2549. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Peng, J. Zhu, Y. Hwangbo, L. Corey, and R. E. Bumgarner Independent and Cooperative Antiviral Actions of Beta Interferon and Gamma Interferon against Herpes Simplex Virus Replication in Primary Human Fibroblasts J. Virol., February 15, 2008; 82(4): 1934 - 1945. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Dummer, A. Hauschild, J. C. Becker, J.-J. Grob, D. Schadendorf, V. Tebbs, J. Skalsky, K. C. Kaehler, S. Moosbauer, R. Clark, et al. An Exploratory Study of Systemic Administration of the Toll-like Receptor-7 Agonist 852A in Patients with Refractory Metastatic Melanoma Clin. Cancer Res., February 1, 2008; 14(3): 856 - 864. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Barber, T. Zhang, and C. L. Sentman Immunotherapy with Chimeric NKG2D Receptors Leads to Long-Term Tumor-Free Survival and Development of Host Antitumor Immunity in Murine Ovarian Cancer J. Immunol., January 1, 2008; 180(1): 72 - 78. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. M. Martin, J. B. Taggart, P. Seear, J. E. Bron, R. Talbot, A. J. Teale, G. E. Sweeney, B. Hoyheim, D. F. Houlihan, D. R. Tocher, et al. Interferon type I and type II responses in an Atlantic salmon (Salmo salar) SHK-1 cell line by the salmon TRAITS/SGP microarray Physiol Genomics, December 19, 2007; 32(1): 33 - 44. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Beekhuizen and J. S. van de Gevel Gamma Interferon Confers Resistance to Infection with Staphylococcus aureus in Human Vascular Endothelial Cells by Cooperative Proinflammatory and Enhanced Intrinsic Antibacterial Activities Infect. Immun., December 1, 2007; 75(12): 5615 - 5626. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Smith, J. S. Moylan, J. D. Smith, W. Li, and M. B. Reid IFN-{gamma} does not mimic the catabolic effects of TNF-{alpha} Am J Physiol Cell Physiol, December 1, 2007; 293(6): C1947 - C1952. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Zhang, A. Barber, and C. L. Sentman Chimeric NKG2D Modified T Cells Inhibit Systemic T-Cell Lymphoma Growth in a Manner Involving Multiple Cytokines and Cytotoxic Pathways Cancer Res., November 15, 2007; 67(22): 11029 - 11036. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Henry, X. Daniell, M. Indaram, J. F. Whitesides, G. D. Sempowski, D. Howell, T. Oliver, and G. A. Taylor Impaired Macrophage Function Underscores Susceptibility to Salmonella in Mice Lacking Irgm1 (LRG-47) J. Immunol., November 15, 2007; 179(10): 6963 - 6972. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Trotta, D. Ciarlariello, J. D. Col, J. Allard II, P. Neviani, R. Santhanam, H. Mao, B. Becknell, J. Yu, A. K. Ferketich, et al. The PP2A inhibitor SET regulates natural killer cell IFN-{gamma} production J. Exp. Med., October 1, 2007; 204(10): 2397 - 2405. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Schroder, M. Spille, A. Pilz, J. Lattin, K. A. Bode, K. M. Irvine, A. D. Burrows, T. Ravasi, H. Weighardt, K. J. Stacey, et al. Differential Effects of CpG DNA on IFN-beta Induction and STAT1 Activation in Murine Macrophages versus Dendritic Cells: Alternatively Activated STAT1 Negatively Regulates TLR Signaling in Macrophages J. Immunol., September 15, 2007; 179(6): 3495 - 3503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Binker, D. Y. Zhao, S. J. Y. Pang, and R. E. Harrison Cytoplasmic Linker Protein-170 Enhances Spreading and Phagocytosis in Activated Macrophages by Stabilizing Microtubules J. Immunol., September 15, 2007; 179(6): 3780 - 3791. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Rose Interferon-{gamma} and Intimal Hyperplasia Circ. Res., September 14, 2007; 101(6): 542 - 544. [Full Text] [PDF]
|
|
|
|
|
|
M. Koga, H. Kai, H. Yasukawa, T. Yamamoto, Y. Kawai, S. Kato, K. Kusaba, M. Kai, K. Egashira, Y. Kataoka, et al. Inhibition of Progression and Stabilization of Plaques by Postnatal Interferon-{gamma} Function Blocking in ApoE-Knockout Mice Circ. Res., August 17, 2007; 101(4): 348 - 356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Cameron, L. Ran, L. Xu, A. Danesh, J. F. Bermejo-Martin, C. M. Cameron, M. P. Muller, W. L. Gold, S. E. Richardson, S. M. Poutanen, et al. Interferon-Mediated Immunopathological Events Are Associated with Atypical Innate and Adaptive Immune Responses in Patients with Severe Acute Respiratory Syndrome J. Virol., August 15, 2007; 81(16): 8692 - 8706. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Tewari, Y. Nakayama, and M. Suresh Role of Direct Effects of IFN-{gamma} on T Cells in the Regulation of CD8 T Cell Homeostasis J. Immunol., August 15, 2007; 179(4): 2115 - 2125. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Tokumasa, A. Suto, S.-i. Kagami, S. Furuta, K. Hirose, N. Watanabe, Y. Saito, K. Shimoda, I. Iwamoto, and H. Nakajima Expression of Tyk2 in dendritic cells is required for IL-12, IL-23, and IFN-{gamma} production and the induction of Th1 cell differentiation Blood, July 15, 2007; 110(2): 553 - 560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Prasanna, B. Saha, and D. Nandi Involvement of oxidative and nitrosative stress in modulation of gene expression and functional responses by IFN{gamma} Int. Immunol., July 2, 2007; (2007) dxm058v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lattin, D. A. Zidar, K. Schroder, S. Kellie, D. A. Hume, and M. J. Sweet G-protein-coupled receptor expression, function, and signaling in macrophages J. Leukoc. Biol., July 1, 2007; 82(1): 16 - 32. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Neff-LaFord, S. Teske, T. P. Bushnell, and B. P. Lawrence Aryl Hydrocarbon Receptor Activation during Influenza Virus Infection Unveils a Novel Pathway of IFN-{gamma} Production by Phagocytic Cells J. Immunol., July 1, 2007; 179(1): 247 - 255. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Brown, Q. Xu, N. Okhubo, M. P. Vitek, and C. A. Colton Androgen-Mediated Immune Function Is Altered by the Apolipoprotein E Gene Endocrinology, July 1, 2007; 148(7): 3383 - 3390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Stout, K. Melendez, J. Seagrave, M. J. Holtzman, B. Wilson, J. Xiang, and Y. Tesfaigzi STAT1 Activation Causes Translocation of Bax to the Endoplasmic Reticulum during the Resolution of Airway Mucous Cell Hyperplasia by IFN-{gamma} J. Immunol., June 15, 2007; 178(12): 8107 - 8116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Schroder, M. Lichtinger, K. M. Irvine, K. Brion, A. Trieu, I. L. Ross, T. Ravasi, K. J. Stacey, M. Rehli, D. A. Hume, et al. PU.1 and ICSBP control constitutive and IFN-{gamma}-regulated Tlr9 gene expression in mouse macrophages J. Leukoc. Biol., June 1, 2007; 81(6): 1577 - 1590. [Abstract] [Full Text] [PDF]
|
|
