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A more recent version of this article appeared on December 1, 2006

Published online before print September 22, 2006
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© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.0506305

Received for publication May 5, 2006.
Revised July 1, 2006.
Accepted for publication August 22, 2006.

Article

Cytokine-induced killer T cells kill immature dendritic cells by TCR-independent and perforin-dependent mechanisms

Pramod S. Joshi *, Jin-Qing Liu *, Yin Wang *, Xing Chang *, John Richards *, Erika Assarsson {dagger}, Fu-Dong Shi {ddagger}, Hans-Gustaf Ljunggren {dagger}, and Xue-Feng Bai *@

*Department of Pathology and Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, Ohio, USA; {dagger}Center for Infectious Medicine, Department of Medicine, Karolinska Institute, F59, Karolinska University Hospital Huddinge, Stockholm, Sweden; and {ddagger}Barrow Neurological Institute, NRC-428, St. Joseph’s Hospital and Medical Center, Phoenix, Arizona, USA

@ To whom correspondence should be addressed. E-mail: Xue-Feng.Bai{at}osumc.edu.


  Abstract

Cytokine-induced killer (CIK) cells are ex vivo, expanded T cells with proven anticancer activity in vitro and in vivo. However, their functional properties with the exception of their cancer cell-killing activity are largely unclear. Here, we show that CIK T cells recognize dendritic cells (DC), and although mature DC (mDC) induce CIK T cells to produce IFN-{gamma}, immature DC (iDC) are killed selectively by them. Moreover, CIK T cell activation by mDC and their destruction of iDC are independent of the TCR. The cytotoxicity of CIK T cells to iDC is perforin-dependent. Our data have revealed an important regulatory role of CIK cells.

Key Words: cytotoxicity • IFN-{gamma} • NK T cells






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