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Published online before print January 14, 2004
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© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.0403194

Received for publication April 30, 2003.
Revised November 23, 2003.
Accepted for publication November 24, 2003.

Article

Regulation of TLR signaling and inflammation by SOCS family proteins

Akihiko Yoshimura @, Hiroyuki Mori Masanobu Ohishi , Daisuke Aki , and Toshikatsu Hanada

Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan

@ To whom correspondence should be addressed. E-mail: yakihiko{at}bioreg.kyushu-u.ac.jp.


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Abstract

Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. These cytokines exert their biological functions through Janus tyrosine kinases and signal transducer and activator of transcription factors. The cytokine-inducible Src homology 2 protein (CIS) and suppressors of cytokine signaling (SOCS) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine responses, including those that regulate the inflammatory systems. In this short review, we focused on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in Toll-like receptor signal regulation and inflammatory diseases.

Key Words: cytokine • tyrosine kinase • Toll-like receptor • STAT • NF-{kappa}B • inflammatory bowel disease • rheumatoid antithesis • endotoxin




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