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Published online before print July 18, 2007

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© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.0307167

Received for publication March 16, 2007.
Revised June 5, 2007.
Accepted for publication June 25, 2007.

Article

Bidirectional MHC molecule exchange between migratory and resident dendritic cells

Magali de Heusch ^*, Didier Blocklet , Dominique Egrise , Bernard Hauquier , Marjorie Vermeersch ^*, Serge Goldman , and Muriel Moser ^*@

*Institut de Biologie et Médecine Moléculaires, Université Libre de Bruxelles, Gosselies, Belgium; and Hopital Erasme, Université Libre de Bruxelles, Brussel, Belgium

^@ To whom correspondence should be addressed. E-mail: mmoser{at}ulb.ac.be.

	Abstract

Dendritic cells (DCs) loaded extracorporeally with antigen can be used as an adjuvant in vivo. In this work, we analyzed the migration of transferred DC and monitored the phenotype of new migrants in the draining lymph nodes. It is surprising that we found that a majority of resident DCs expressed donor MHC molecules and that a proportion of injected DCs acquired host MHC molecules. These observations suggest that a bidirectional MHC molecule exchange occurs between migratory and resident DCs, a mechanism that may amplify antigen presentation in vivo.

Key Words: antigen presentation • expression • interaction • migration • lymph nodes