Published online before print August 21, 2007
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Article |
Laboratory of Experimental Hematology, Faculty of Medicine, Antwerp University, Belgium, and Center for Cell Therapy and Regenerative Medicine, Antwerp University Hospital, Belgium
@ To whom correspondence should be addressed. E-mail: nathalie.cools{at}uza.be.
Dendritic cells (DC), professional antigen-presenting cells of the immune system, exert important functions both in induction of T cell immunity, as well as tolerance. It is well established that the main function of immature DC (iDC) in their in vivo steady-state condition is to maintain peripheral tolerance to self-antigens and that these iDC mature upon encounter of so-called danger signals and subsequently promote T cell immunity. Previously, it was believed that T cell unresponsiveness induced after stimulation with iDC is caused by the absence of inflammatory signals in steady-state in vivo conditions and by the low expression levels of costimulatory molecules on iDC. However, a growing body of evidence now indicates that iDC can also actively maintain peripheral T cell tolerance by the induction and/or stimulation of regulatory T cell populations. Moreover, several reports indicate that traditional DC maturation can no longer be used to distinguish tolerogenic and immunogenic properties of DC. This review will focus on the complementary role of dendritic cells in inducing both tolerance and immunity, and we will discuss the clinical implications for dendritic cell-based therapies.
Key Words: bone marrow • Langerhans cells • interferon
This article has been cited by other articles:
 |
|
 |
|
  J. L. Blanchfield and M. D. Mannie A GMCSF-neuroantigen fusion protein is a potent tolerogen in experimental autoimmune encephalomyelitis (EAE) that is associated with efficient targeting of neuroantigen to APC J. Leukoc. Biol., March 1, 2010; 87(3): 509 - 521. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Evrard, D. Balestrino, A. Dosgilbert, J.-L. J. Bouya-Gachancard, N. Charbonnel, C. Forestier, and A. Tridon Roles of Capsule and Lipopolysaccharide O Antigen in Interactions of Human Monocyte-Derived Dendritic Cells and Klebsiella pneumoniae Infect. Immun., January 1, 2010; 78(1): 210 - 219. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. Spurrell, N. A. Luckashenak, D. C. Minney, A. Chaplin, J. M. Penninger, R. S. Liwski, J. L. Clements, and K. A. West Vav1 Regulates the Migration and Adhesion of Dendritic Cells J. Immunol., July 1, 2009; 183(1): 310 - 318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Karumuthil-Melethil, N. Perez, R. Li, and C. Vasu Induction of Innate Immune Response through TLR2 and Dectin 1 Prevents Type 1 Diabetes J. Immunol., December 15, 2008; 181(12): 8323 - 8334. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Farrell, C. Zaupa, Z. Barnard, J. Maley, R. L. Martuza, S. D. Rabkin, and W. T. Curry Jr. Combination Immunotherapy for Tumors via Sequential Intratumoral Injections of Oncolytic Herpes Simplex Virus 1 and Immature Dendritic Cells Clin. Cancer Res., December 1, 2008; 14(23): 7711 - 7716. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. K. Vassiliou, O. M. Kesler, J. H. Tadros, and D. Ganea Bone Marrow-Derived Dendritic Cells Generated in the Presence of Resolvin E1 Induce Apoptosis of Activated CD4+ T Cells J. Immunol., October 1, 2008; 181(7): 4534 - 4544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Van Overtvelt, E. Wambre, B. Maillere, E. von Hofe, A. Louise, A. M. Balazuc, B. Bohle, D. Ebo, C. Leboulaire, G. Garcia, et al. Assessment of Bet v 1-Specific CD4+ T Cell Responses in Allergic and Nonallergic Individuals Using MHC Class II Peptide Tetramers J. Immunol., April 1, 2008; 180(7): 4514 - 4522. [Abstract] [Full Text] [PDF]
|
|
