HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

Published online before print August 30, 2006

This Article Full Text (Reprint (PDF)) All Versions of this Article: jlb.0306170v1 81/1/28    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Foell, D. Articles by Roth, J. Search for Related Content PubMed PubMed Citation Articles by Foell, D. Articles by Roth, J.

© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.0306170

Received for publication March 5, 2006.
Revised May 11, 2006.
Accepted for publication May 13, 2006.

Article

S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules

Dirk Foell ^*, Helmut Wittkowski ^*, Thomas Vogl , and Johannes Roth ^*@

*Department of Pediatrics and Institute of Experimental Dermatology, University of Muenster, Germany

^@ To whom correspondence should be addressed. E-mail: rothj{at}uni-muenster.de.

	Abstract

Damage-associated molecular pattern (DAMP) molecules have been introduced as important proinflammatory factors of innate immunity. One example known for many years to be expressed in cells of myeloid origin are phagocytic S100 proteins, which mediate inflammatory responses and recruit inflammatory cells to sites of tissue damage. An emerging concept of pattern recognition involves the multiligand receptor for advanced glycation end products (RAGE) and Toll-like receptors (TLRs) in sensing not only pathogen-associated molecular patterns (PAMPs) but also endogenous DAMPs, including S100 proteins. S100A8, S100A9, and S100A12 are found at high concentrations in inflamed tissue, where neutrophils and monocytes belong to the most abundant cell types. They exhibit proinflammatory effects in vitro at concentrations found at sites of inflammation in vivo. Although S100A12 binds to RAGE, at least part of the proinflammatory effects of the S100A8/S100A9 complex depend upon interaction with other receptors. Because of the divergent expression patterns, the absence of S100A12 in rodents, the different interaction partners described, and the specific intracellular and extracellular effects reported for these proteins, it is important to differentiate between distinct S100 proteins rather than subsuming them with the term "S100/calgranulins." Analyzing the molecular basis of the specific effects exhibited by these proteins in greater detail bears the potential to elucidate important mechanisms of innate immunity, to establish valid biomarkers of phagocytic inflammation, and eventually to reveal novel targets for innovative anti-inflammatory therapies.

This article has been cited by other articles:

				P L E M van Lent, L Grevers, A B Blom, A Sloetjes, J S Mort, T Vogl, W Nacken, W B van den Berg, and J Roth Myeloid-related proteins S100A8/S100A9 regulate joint inflammation and cartilage destruction during antigen-induced arthritis Ann Rheum Dis, December 1, 2008; 67(12): 1750 - 1758. [Abstract] [Full Text] [PDF]

				S. J. Caillier, F. Briggs, B. A. C. Cree, S. E. Baranzini, M. Fernandez-Vina, P. P. Ramsay, O. Khan, W. Royal III, S. L. Hauser, L. F. Barcellos, et al. Uncoupling the Roles of HLA-DRB1 and HLA-DRB5 Genes in Multiple Sclerosis J. Immunol., October 15, 2008; 181(8): 5473 - 5480. [Abstract] [Full Text] [PDF]

				R. F. Savaris, A. E. Hamilton, B. A. Lessey, and L. C. Giudice Endometrial Gene Expression in Early Pregnancy: Lessons From Human Ectopic Pregnancy Reproductive Sciences, October 1, 2008; 15(8): 797 - 816. [Abstract] [PDF]

				P. Sinha, C. Okoro, D. Foell, H. H. Freeze, S. Ostrand-Rosenberg, and G. Srikrishna Proinflammatory S100 Proteins Regulate the Accumulation of Myeloid-Derived Suppressor Cells J. Immunol., October 1, 2008; 181(7): 4666 - 4675. [Abstract] [Full Text] [PDF]

				O. Turovskaya, D. Foell, P. Sinha, T. Vogl, R. Newlin, J. Nayak, M. Nguyen, A. Olsson, P. P. Nawroth, A. Bierhaus, et al. RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis Carcinogenesis, October 1, 2008; 29(10): 2035 - 2043. [Abstract] [Full Text] [PDF]

				P. Pouliot, I. Plante, M.-A. Raquil, P. A. Tessier, and M. Olivier Myeloid-Related Proteins Rapidly Modulate Macrophage Nitric Oxide Production during Innate Immune Response J. Immunol., September 1, 2008; 181(5): 3595 - 3601. [Abstract] [Full Text] [PDF]

				R. Wolf, O. M. Z. Howard, H.-F. Dong, C. Voscopoulos, K. Boeshans, J. Winston, R. Divi, M. Gunsior, P. Goldsmith, B. Ahvazi, et al. Chemotactic Activity of S100A7 (Psoriasin) Is Mediated by the Receptor for Advanced Glycation End Products and Potentiates Inflammation with Highly Homologous but Functionally Distinct S100A15 J. Immunol., July 15, 2008; 181(2): 1499 - 1506. [Abstract] [Full Text] [PDF]

				C. A. Mares, S. S. Ojeda, E. G. Morris, Q. Li, and J. M. Teale Initial Delay in the Immune Response to Francisella tularensis Is Followed by Hypercytokinemia Characteristic of Severe Sepsis and Correlating with Upregulation and Release of Damage-Associated Molecular Patterns Infect. Immun., July 1, 2008; 76(7): 3001 - 3010. [Abstract] [Full Text] [PDF]

				D. de Seny, M. Fillet, C. Ribbens, R. Maree, M.-A. Meuwis, L. Lutteri, J.-P. Chapelle, L. Wehenkel, E. Louis, M.-P. Merville, et al. Monomeric Calgranulins Measured by SELDI-TOF Mass Spectrometry and Calprotectin Measured by ELISA as Biomarkers in Arthritis Clin. Chem., June 1, 2008; 54(6): 1066 - 1075. [Abstract] [Full Text] [PDF]

				W. X. Yan, C. Armishaw, J. Goyette, Z. Yang, H. Cai, P. Alewood, and C. L. Geczy Mast Cell and Monocyte Recruitment by S100A12 and Its Hinge Domain J. Biol. Chem., May 9, 2008; 283(19): 13035 - 13043. [Abstract] [Full Text] [PDF]

				F. Martinon Detection of immune danger signals by NALP3 J. Leukoc. Biol., March 1, 2008; 83(3): 507 - 511. [Abstract] [Full Text] [PDF]

				M. Frosch and J. Roth New insights in systemic juvenile idiopathic arthritis--from pathophysiology to treatment Rheumatology, February 1, 2008; 47(2): 121 - 125. [Abstract] [Full Text] [PDF]

				M. D. Behrens, W. M. Wagner, C. J. Krco, C. L. Erskine, K. R. Kalli, J. Krempski, E. A. Gad, M. L. Disis, and K. L. Knutson The endogenous danger signal, crystalline uric acid, signals for enhanced antibody immunity Blood, February 1, 2008; 111(3): 1472 - 1479. [Abstract] [Full Text] [PDF]

				T Kaiser, J Langhorst, H Wittkowski, K Becker, A W Friedrich, A Rueffer, G J Dobos, J Roth, and D Foell Faecal S100A12 as a non-invasive marker distinguishing inflammatory bowel disease from irritable bowel syndrome Gut, December 1, 2007; 56(12): 1706 - 1713. [Abstract] [Full Text] [PDF]

				M. E. Bianchi DAMPs, PAMPs and alarmins: all we need to know about danger J. Leukoc. Biol., January 1, 2007; 81(1): 1 - 5. [Abstract] [Full Text] [PDF]