HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

Published online before print December 9, 2004

This Article Full Text (Reprint (PDF)) All Versions of this Article: jlb.0304212v1 77/3/321    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Raes, G. Articles by Ghassabeh, G. H. Search for Related Content PubMed PubMed Citation Articles by Raes, G. Articles by Ghassabeh, G. H.

© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.0304212

Received for publication March 31, 2004.
Revised November 12, 2004.
Accepted for publication November 15, 2004.

Article

Macrophage galactose-type C-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation

Geert Raes ^*@, Lea Brys ^*, Bhola K. Dahal ^*, Jef Brandt , Johan Grooten , Frank Brombacher , Guido Vanham ^¶, Wim Noël ^*, Pieter Bogaert , Tom Boonefaes , Anne Kindt ^*, Rafaël Van den Bergh ^*, Pieter J. M. Leenen ^||, Patrick De Baetselier ^*, and Gholamreza Hassanzadeh Ghassabeh ^*

*Laboratory of Cellular and Molecular Immunology, Department of Molecular and Cellular Interactions, Vlaams Interuniversitair Instituut voor Biotechnologie, Vrije Universiteit Brussel, Brussles, Belgium; Departments of Veterinary Medicine and ^¶Microbiology, Laboratory of Immunology, Institute for Tropical Medicine, Antwerp, Belgium; Department of Molecular Biomedical Research, Vlaams Interuniversitair Instituut voor Biotechnologie, Ghent University, Belgium; Department of Immunology, University of Cape Town, Groote Schuur Hospital, South Africa; and ^||Department of Immunology, Erasmus MC, Rotterdam, The Netherlands

^@ To whom correspondence should be addressed. E-mail: Geert.Raes{at}vub.ac.be.

	Abstract

Molecular markers, especially surface markers associated with type II, cytokine-dependent, alternatively activated macrophages (aaMF), remain scarce. Besides the earlier documented markers, macrophage mannose receptor and arginase 1, we demonstrated recently that murine aaMF are characterized by increased expression of found in inflammatory zone 1 and Ym. We now document that expression of the two members of the mouse macrophage galactose-type C-type lectin gene family (mMGL1 and mMGL2) is induced in diverse populations of aaMF, including peritoneal macrophages elicited during infection with the protozoan Trypanosoma brucei brucei or the Helminth Taenia crassiceps and alveolar macrophages elicited in a mouse model of allergic asthma. In addition, we demonstrate that in vitro, interleukin-4 (IL-4) and IL-13 up-regulate mMGL1 and mMGL2 expression and that in vivo, induction of mMGL1 and mMGL2 is dependent on IL-4 receptor signaling. Moreover, we show that expression of MGL on human monocytes is also up-regulated by IL-4. Hence, macrophage galactose-type C-type lectins represent novel surface markers for murine and human aaMF.

Key Words: subtracted cDNA • type II cytokines • alveolar macrophages • monocytes

This article has been cited by other articles:

				M. P. Holt, L. Cheng, and C. Ju Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury J. Leukoc. Biol., December 1, 2008; 84(6): 1410 - 1421. [Abstract] [Full Text] [PDF]

				M. C. Siracusa, J. J. Reece, J. F. Urban Jr., and A. L. Scott Dynamics of lung macrophage activation in response to helminth infection J. Leukoc. Biol., December 1, 2008; 84(6): 1422 - 1433. [Abstract] [Full Text] [PDF]

				C. N. Lumeng, J. B. DelProposto, D. J. Westcott, and A. R. Saltiel Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes Diabetes, December 1, 2008; 57(12): 3239 - 3246. [Abstract] [Full Text] [PDF]

				A. C. MacKinnon, S. L. Farnworth, P. S. Hodkinson, N. C. Henderson, K. M. Atkinson, H. Leffler, U. J. Nilsson, C. Haslett, S. J. Forbes, and T. Sethi Regulation of Alternative Macrophage Activation by Galectin-3 J. Immunol., February 15, 2008; 180(4): 2650 - 2658. [Abstract] [Full Text] [PDF]

				T. Raymond, M. Schaller, C. M. Hogaboam, N. W. Lukacs, R. Rochford, and S. L. Kunkel Toll-like Receptors, Notch Ligands, and Cytokines Drive the Chronicity of Lung Inflammation Proceedings of the ATS, December 1, 2007; 4(8): 635 - 641. [Abstract] [Full Text] [PDF]

				B. Stijlemans, T. N. Baral, M. Guilliams, L. Brys, J. Korf, M. Drennan, J. Van Den Abbeele, P. De Baetselier, and S. Magez A Glycosylphosphatidylinositol-Based Treatment Alleviates Trypanosomiasis-Associated Immunopathology J. Immunol., September 15, 2007; 179(6): 4003 - 4014. [Abstract] [Full Text] [PDF]

				A. Mishra, M. Wang, J. Schlotman, N. M. Nikolaidis, C. W. DeBrosse, M. L. Karow, and M. E. Rothenberg Resistin-like molecule-beta is an allergen-induced cytokine with inflammatory and remodeling activity in the murine lung Am J Physiol Lung Cell Mol Physiol, August 1, 2007; 293(2): L305 - L313. [Abstract] [Full Text] [PDF]

				Y. Sano, K. Usami, R. Izawa, K. Denda-Nagai, N. Higashi, T. Kimura, N. Suzuki, and T. Irimura Properties of Blocking and Non-blocking Monoclonal Antibodies Specific for Human Macrophage Galactose-type C-type Lectin (MGL/ClecSF10A/CD301) J. Biochem., January 1, 2007; 141(1): 127 - 136. [Abstract] [Full Text] [PDF]

				N. Devoogdt, H. Revets, A. Kindt, Y. Q. Liu, P. De Baetselier, and G. H. Ghassabeh The Tumor-Promoting Effect of TNF-{alpha} Involves the Induction of Secretory Leukocyte Protease Inhibitor J. Immunol., December 1, 2006; 177(11): 8046 - 8052. [Abstract] [Full Text] [PDF]

				G. Caljon, J. Van Den Abbeele, B. Stijlemans, M. Coosemans, P. De Baetselier, and S. Magez Tsetse Fly Saliva Accelerates the Onset of Trypanosoma brucei Infection in a Mouse Model Associated with a Reduced Host Inflammatory Response Infect. Immun., November 1, 2006; 74(11): 6324 - 6330. [Abstract] [Full Text] [PDF]

				M. Dupasquier, P. Stoitzner, H. Wan, D. Cerqueira, A. van Oudenaren, J. S. A. Voerman, K. Denda-Nagai, T. Irimura, G. Raes, N. Romani, et al. The dermal microenvironment induces the expression of the alternative activation marker CD301/mMGL in mononuclear phagocytes, independent of IL-4/IL-13 signaling J. Leukoc. Biol., October 1, 2006; 80(4): 838 - 849. [Abstract] [Full Text] [PDF]

				J. J. Reece, M. C. Siracusa, and A. L. Scott Innate Immune Responses to Lung-Stage Helminth Infection Induce Alternatively Activated Alveolar Macrophages Infect. Immun., September 1, 2006; 74(9): 4970 - 4981. [Abstract] [Full Text] [PDF]

				N. Wang, M. Campo, L. Ting, C. Fleming, C. Terhorst, and P. W. Finn The Costimulatory Molecule SLAM Is Critical for Pulmonary Allergic Responses Am. J. Respir. Cell Mol. Biol., August 1, 2006; 35(2): 206 - 210. [Abstract] [Full Text] [PDF]

				J. A. Van Ginderachter, S. Meerschaut, Y. Liu, L. Brys, K. De Groeve, G. Hassanzadeh Ghassabeh, G. Raes, and P. De Baetselier Peroxisome proliferator-activated receptor {gamma} (PPAR{gamma}) ligands reverse CTL suppression by alternatively activated (M2) macrophages in cancer Blood, July 15, 2006; 108(2): 525 - 535. [Abstract] [Full Text] [PDF]

				G. Hassanzadeh Ghassabeh, P. De Baetselier, L. Brys, W. Noel, J. A. Van Ginderachter, S. Meerschaut, A. Beschin, F. Brombacher, and G. Raes Identification of a common gene signature for type II cytokine-associated myeloid cells elicited in vivo in different pathologic conditions Blood, July 15, 2006; 108(2): 575 - 583. [Abstract] [Full Text] [PDF]

				M. Joerink, C. M. S. Ribeiro, R. J. M. Stet, T. Hermsen, H. F. J. Savelkoul, and G. F. Wiegertjes Head Kidney-Derived Macrophages of Common Carp (Cyprinus carpio L.) Show Plasticity and Functional Polarization upon Differential Stimulation J. Immunol., July 1, 2006; 177(1): 61 - 69. [Abstract] [Full Text] [PDF]

				A. Erdely, D. Kepka-Lenhart, M. Clark, P. Zeidler-Erdely, M. Poljakovic, W. J. Calhoun, and S. M. Morris Jr Inhibition of phosphodiesterase 4 amplifies cytokine-dependent induction of arginase in macrophages Am J Physiol Lung Cell Mol Physiol, March 1, 2006; 290(3): L534 - L539. [Abstract] [Full Text] [PDF]

				S. K. Biswas, L. Gangi, S. Paul, T. Schioppa, A. Saccani, M. Sironi, B. Bottazzi, A. Doni, B. Vincenzo, F. Pasqualini, et al. A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-{kappa}B and enhanced IRF-3/STAT1 activation) Blood, March 1, 2006; 107(5): 2112 - 2122. [Abstract] [Full Text] [PDF]

				G. Raes, R. Van den Bergh, P. De Baetselier, G. H. Ghassabeh, C. Scotton, M. Locati, A. Mantovani, and S. Sozzani Arginase-1 and Ym1 Are Markers for Murine, but Not Human, Alternatively Activated Myeloid Cells J. Immunol., June 1, 2005; 174(11): 6561 - 6562. [Full Text] [PDF]

				L. Brys, A. Beschin, G. Raes, G. H. Ghassabeh, W. Noel, J. Brandt, F. Brombacher, and P. D. Baetselier Reactive Oxygen Species and 12/15-Lipoxygenase Contribute to the Antiproliferative Capacity of Alternatively Activated Myeloid Cells Elicited during Helminth Infection J. Immunol., May 15, 2005; 174(10): 6095 - 6104. [Abstract] [Full Text] [PDF]