| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
Published online before print April 23, 2004
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Article |
-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions
,,,
*The Edward Jenner Institute for Vaccine Research, Compton, Berkshire, United Kingdom; and Sir William Dunn School of Pathology, Oxford University, United Kingdom
@ To whom correspondence should be addressed. E-mail: delyth.wong{at}jenner.ac.uk.
 |
Abstract |
|---|
Dectin-1 is a pathogen-recognition receptor on macrophages (M|RAs), neutrophils, and dendritic cells (DCs). On M|RAs and bone marrow-derived DCs, it has been shown to mediate the nonopsonic recognition of and response to soluble and particulate yeast 
-glucans. We have optimized the immunohistochemical detection of Dectin-1 and demonstrated its expression on neutrophils, subpopulations of M|RAs in splenic red and white pulp, alveolar M|RAs, Kupffer cells, and M|RAs and DCs in the lamina propria of gut villi. This is consistent with its role in pathogen surveillance. A significant proportion of CD11c+ splenic DCs expressed Dectin-1, but expression was not restricted to any one subset. Dectin-1 expression was low on resident M|RAs and DCs of skin and was not detected on resident M|RAs or DCs in kidney, heart, brain, or eye. The proposed, additional role of Dectin-1 as a coreceptor for T cell activation is supported by its expression on DCs in the T cell areas of the spleen and lymph nodes. Strong expression of Dectin-1 on subpopulations of M|RAs and DCs in the medullary and corticomedullary regions of the thymus suggests a role distinct from pathogen recognition. Tissue localization thus revealed potential roles of Dectin-1 in leukocyte interactions during innate immune responses and T cell development.
Key Words: innate immunity • macrophages • dendritic cells • spleen • thymus development
This article has been cited by other articles:
|
|
 |
|
  S. LeibundGut-Landmann, F. Osorio, G. D. Brown, and C. Reis e Sousa Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses Blood, December 15, 2008; 112(13): 4971 - 4980. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. B. Tarabishy, B. Aldabagh, Y. Sun, Y. Imamura, P. K. Mukherjee, J. H. Lass, M. A. Ghannoum, and E. Pearlman MyD88 Regulation of Fusarium Keratitis Is Dependent on TLR4 and IL-1R1 but Not TLR2 J. Immunol., July 1, 2008; 181(1): 593 - 600. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Wells, J. A. Salvage-Jones, X. Li, K. Hitchens, S. Butcher, R. Z. Murray, A. G. Beckhouse, Y.-L.-S. Lo, S. Manzanero, C. Cobbold, et al. The Macrophage-Inducible C-Type Lectin, Mincle, Is an Essential Component of the Innate Immune Response to Candida albicans J. Immunol., June 1, 2008; 180(11): 7404 - 7413. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Koneti, M. J. Linke, E. Brummer, and D. A. Stevens Evasion of Innate Immune Responses: Evidence for Mannose Binding Lectin Inhibition of Tumor Necrosis Factor Alpha Production by Macrophages in Response to Blastomyces dermatitidis Infect. Immun., March 1, 2008; 76(3): 994 - 1002. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. G. Rothfuchs, A. Bafica, C. G. Feng, J. G. Egen, D. L. Williams, G. D. Brown, and A. Sher Dectin-1 Interaction with Mycobacterium tuberculosis Leads to Enhanced IL-12p40 Production by Splenic Dendritic Cells J. Immunol., September 15, 2007; 179(6): 3463 - 3471. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Vermijlen, P. Ellis, C. Langford, A. Klein, R. Engel, K. Willimann, H. Jomaa, A. C. Hayday, and M. Eberl Distinct Cytokine-Driven Responses of Activated Blood {gamma}{delta} T Cells: Insights into Unconventional T Cell Pleiotropy J. Immunol., April 1, 2007; 178(7): 4304 - 4314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Gays, J. G. Aust, D. M. Reid, J. Falconer, N. Toyama-Sorimachi, P. R. Taylor, and C. G. Brooks Ly49B Is Expressed on Multiple Subpopulations of Myeloid Cells J. Immunol., November 1, 2006; 177(9): 5840 - 5851. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Carter, C. Thompson, D. M. Reid, S. Y. C. Wong, and D. F. Tough Preferential Induction of CD4+ T Cell Responses through In Vivo Targeting of Antigen to Dendritic Cell-Associated C-Type Lectin-1 J. Immunol., August 15, 2006; 177(4): 2276 - 2284. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Palma, T. Feizi, Y. Zhang, M. S. Stoll, A. M. Lawson, E. Diaz-Rodriguez, M. A. Campanero-Rhodes, J. Costa, S. Gordon, G. D. Brown, et al. Ligands for the beta-Glucan Receptor, Dectin-1, Assigned Using "Designer" Microarrays of Oligosaccharide Probes (Neoglycolipids) Generated from Glucan Polysaccharides J. Biol. Chem., March 3, 2006; 281(9): 5771 - 5779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Suram, G. D. Brown, M. Ghosh, S. Gordon, R. Loper, P. R. Taylor, S. Akira, S. Uematsu, D. L. Williams, and C. C. Leslie Regulation of Cytosolic Phospholipase A2 Activation and Cyclooxygenase 2 Expression in Macrophages by the beta-Glucan Receptor J. Biol. Chem., March 3, 2006; 281(9): 5506 - 5514. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. C. Parker, M. K. B. Whyte, S. K. Dower, and I. Sabroe The expression and roles of Toll-like receptors in the biology of the human neutrophil J. Leukoc. Biol., June 1, 2005; 77(6): 886 - 892. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Moghimi, A. C. Hunter, and J. C. Murray Nanomedicine: current status and future prospects FASEB J, March 1, 2005; 19(3): 311 - 330. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
