HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

Published online before print October 15, 2007

This Article Full Text Full Text (PDF) All Versions of this Article: jlb.0607369v1 83/3/518    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Choudhry, M. A. Articles by Chaudry, I. H. Search for Related Content PubMed PubMed Citation Articles by Choudhry, M. A. Articles by Chaudry, I. H.

(Journal of Leukocyte Biology. 2008;83:518-522.)
© 2008 by Society for Leukocyte Biology

17β-Estradiol: a novel hormone for improving immune and cardiovascular responses following trauma-hemorrhage

Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA

¹Correspondence: Center for Surgical Research, The University of Alabama at Birmingham, Volker Hall G094, 1670 University Blvd., Birmingham, AL 35294-0019, USA. E-mail: irshad.chaudry{at}ccc.uab.edu

ABSTRACT

17β-Estradiol (i.e., estrogen or E2) is a female sex steroid, which plays an essential role in female reproductive physiology. However, several lines of evidence indicate that in addition to its role in reproductive physiology, E2 is critical for maintaining many other organ functions in stress conditions. These include immune, cardiovascular, and neuronal functions, as well as regulation of skin, bone, and lipid metabolism. Studies have examined the role of E2 as an adjunct in post-trauma responses, and this article will review whether E2 as an adjunct to fluid resuscitation following trauma-hemorrhage plays any role in improving/restoring immune and cardiovascular functions.

Key Words: ER-a • ER-β • cytokines • shock • cell signaling • Kupffer cells