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Published online before print November 29, 2006

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(Journal of Leukocyte Biology. 2007;81:584-592.)
© 2007 by Society for Leukocyte Biology

The CD14+ CD16+ blood monocytes: their role in infection and inflammation

Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK; and Clinical Cooperation Group, Inflammatory Lung Diseases, GSF and Asklepios-Kliniken, Gauting, Germany

¹ Correspondence: Department of Infection, Immunity and Inflammation, University of Leicester, Medical Sciences Building, University Road, Leicester, LE1 9HN, UK. E-mail: lzh1{at}le.ac.uk

Blood monocyte subpopulations have been defined in man initially, and the two major types of monocytes are the CD14++ CD16– and the CD14+ CD16+ monocytes. These cells have been shown to exhibit distinct phenotype and function, and the CD14+ CD16+ were labeled proinflammatory based on higher expression of proinflammatory cytokines and higher potency in antigen presentation. The current review describes these properties, including the relationship to dendritic cells, and summarizes the host of publications about CD14+ CD16+ monocytes in inflammation and infectious disease in man, all of which suggest a crucial role of these cells in the disease processes. The review also covers the more recent description of homologues of these cells in other model species, which is expected to better define the role of monocyte subsets in disease.

Key Words: cytokines • migration • HIV • arthritis • atherosclerosis

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