Journal of Leukocyte Biology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published online as doi:10.1189/jlb.0206094 on June 29, 2006

Published online before print June 29, 2006
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
jlb.0206094v1
80/3/471    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chaput, N.
Right arrow Articles by Zitvogel, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chaput, N.
Right arrow Articles by Zitvogel, L.
(Journal of Leukocyte Biology. 2006;80:471-478.)
© 2006 by Society for Leukocyte Biology

Dendritic cell derived-exosomes: biology and clinical implementations

Nathalie Chaput*,1, Caroline Flament*, Sophie Viaud*, Julien Taieb*, Stephan Roux*, Alain Spatz{dagger}, Fabrice André*, Jean-Bernard LePecq{ddagger}, Muriel Boussac§, Jérôme Garin§, Sebastian Amigorena, Clotilde Théry and Laurence Zitvogel*

* ERM0208 Institut National de la Santé Et de la Recherche Médicale, Faculté de Médecine Paris Sud-Université Paris XI, and
{dagger} Department of Biology and Pathology, Institut Gustave Roussy, Villejuif, France;
{ddagger} Anosys Inc., Menlo Park, California;
§ Laboratoire de chimie des protéines, Centre d’Energie Atomique, Grenoble, France; and
U520/U365, INSERM, Institut Curie, Paris, France

1 Correspondence at current address: CIC Biotherapie, Institut Gustave Roussy, Villeneuf 94805, France. E-mail: chaput{at}igr.fr

Exosomes are nanometer-sized membrane vesicles invaginating from multivesicular bodies and secreted from different cell types. They represent an "in vitro" discovery, but vesicles with the hallmarks of exosomes are present in vivo in germinal centers and biological fluids. Their protein and lipid composition is unique and could account for their expanding functions such as eradication of obsolete proteins, antigen presentation, or "Trojan horses" for viruses or prions. The potential of dendritic cell-derived exosomes (Dex) as cell-free cancer vaccines is addressed in this review. Lessons learned from the pioneering clinical trials allowed reassessment of the priming capacities of Dex in preclinical models, optimizing clinical protocols, and delineating novel, biological features of Dex in cancer patients.

Key Words: cytotoxic T lymphocytes • NK cells • tumor immunotherapy • clinical trial




This article has been cited by other articles:


Home page
 J. Immunol.Home page
A. Busch, T. Quast, S. Keller, W. Kolanus, P. Knolle, P. Altevogt, and A. Limmer
Transfer of T Cell Surface Molecules to Dendritic Cells upon CD4+ T Cell Priming Involves Two Distinct Mechanisms
J. Immunol., September 15, 2008; 181(6): 3965 - 3973.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Islam, H. Jones, T. Hiroi, J. Lam, J. Zhang, J. Moss, M. Vaughan, and S. J. Levine
cAMP-dependent Protein Kinase A (PKA) Signaling Induces TNFR1 Exosome-like Vesicle Release via Anchoring of PKA Regulatory Subunit RII{beta} to BIG2
J. Biol. Chem., September 12, 2008; 283(37): 25364 - 25371.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. Bhatnagar, K. Shinagawa, F. J. Castellino, and J. S. Schorey
Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo
Blood, November 1, 2007; 110(9): 3234 - 3244.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2006 by the Society for Leukocyte Biology.