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Published online before print May 9, 2006

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(Journal of Leukocyte Biology. 2006;80:16-23.)
© 2006 by Society for Leukocyte Biology

The generation and modulation of antigen-specific memory CD8 T cell responses

Ali Jabbari^* and John T. Harty^*,,1

^* Interdisciplinary Graduate Program in Immunology and
Department of Microbiology, University of Iowa, Iowa City

¹ Correspondence: Department of Microbiology, University of Iowa, 3-512 Bowen Science Building, 51 Newton Rd., Iowa City, IA 52242. E-mail: john-harty{at}uiowa.edu

The immune system has adapted to effect different mechanisms to combat the multitude of potential pathogens in our environment. In particular, CD8 T cells are participants in the immune response to intracellular pathogens, which include viruses, certain types of bacteria, and protozoa. Classified as members of the adaptive immune system, antigen-specific CD8 T cells after activation eventually form a pool of memory. Memory cells have an enhanced ability to protect against subsequent infections. The generation of antigen-specific CD8 T cells, therefore, is a potential approach in the design of vaccines, especially for those pathogens in which the humoral response is insufficient to protect the host.

Key Words: vaccination • adaptive immunity • acute infection

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