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Originally published online as doi:10.1189/jlb.0905537 on December 19, 2005

Published online before print December 19, 2005
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(Journal of Leukocyte Biology. 2006;79:417-424.)
© 2006 by Society for Leukocyte Biology

Fine-tuning of immune responses by SLAM-related receptors

Rauf Bhat, Philipp Eissmann, Johanna Endt, Sabrina Hoffmann and Carsten Watzl1

Institute for Immunology, University Heidelberg, Germany

1 Correspondence: Institute for Immunology, University Heidelberg, INF 305, 69120 Heidelberg, Germany. E-mail: carsten.watzl{at}urz.uni-heidelberg.de

The modulation of antigen receptor signals is important for a productive immune response. The main function of the recently identified members of the signaling lymphocyte activating molecule (SLAM)-related receptors (SRR) is the fine-tuning of immune cell activation. Disruption of SRR function is the cause for severe immune disorders such as X-linked lymphoproliferative syndrome (XLP), where XLP patients carry a mutation in SLAM-associated protein (SAP) (SH2D1A), an important adaptor molecule for the signal transduction of SRR. Recent data also suggest that SRR may play a role in autoimmune diseases and the function of hematopoietic stem and progenitor cells. Here, we review the current understanding of SRR function in different immune cells.

Key Words: T cells • NK cells • activation • costimulation • Th1/2 polarization




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