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Published online before print August 4, 2005
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and Th1 chemokine production
,1
,3
,4
* Laboratory for Immunological Research, Schering-Plough Research Institute, Dardilly, France;
INSERM U590, Centre Léon Bérard, Lyon, France;
DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California;
Department of Research and Development, Research Group on Lymphoma, EFS Rhône-Alpes Grenoble, La Tronche, France; and
|| University of Minnesota Cancer Center, Minneapolis, Minnesota
1Correspondence: INSERM U590, Centre Léon Bérard, Lyon, France. E-mail: bendris{at}lyon.fnclcc.fr
Depending on the activation status, plasmacytoid dendritic cells (PDC) and myeloid DC have the ability to induce CD4 T cell development toward T helper cell type 1 (Th1) or Th2 pathways. Thus, we tested whether different activation signals could also have an impact on the profile of chemokines produced by human PDC. Signals that induce human PDC to promote a type 1 response (i.e., viruses) and a type 2 response [i.e., CD40 ligand (CD40L)] also induced PDC isolated from tonsils to secrete chemokines preferentially attracting Th1 cells [such as interferon-
(IFN-)-inducible protein (IP)-10/CXC chemokine ligand 10 (CXCL10) and macrophage inflammatory protein-1ß/CC chemokine ligand 4 (CCL4)] or Th2 cells (such as thymus and activation-regulated chemokine/CCL17 and monocyte-derived chemokine/CCL22), respectively. Activated natural killer cells were preferentially recruited by supernatants of virus-activated PDC, and supernatants of CD40L-activated PDC attracted memory CD4+ T cells, particularly the CD4+CD45RO+CD25+ T cells described for their regulatory activities. It is striking that CD40L and virus synergized to trigger the production of IFN- by PDC, which induces another Th1-attracting chemokine monokine-induced by IFN-/CXCL9 and cooperates with endogenous type I IFN for IP-10/CXCL10 production. In conclusion, our studies reveal that PDC participate in the selective recruitment of effector cells of innate and adaptive immune responses and that virus converts the CD40L-induced Th2 chemokine patterns of PDC into a potent Th1 mediator profile through an autocrine loop of IFN-.
Key Words: PDC • migration • memory T cells • NK cells • chemokines
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