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(Journal of Leukocyte Biology. 2003;73:1-2.)
© 2003 by Society for Leukocyte Biology

2002 DOLPH ADAMS AWARD

It has been 6 years since the council of the Society of Leukocyte Biology initiated cash awards in honor of Dolph Adams. The $1000 award, which was established to recognize the most highly cited research paper and review article published in the Journal of Leukocyte Biology, is based on the number of citations over the last 5 years and gauges the effect of the papers on the scientific community. The prizes are awarded to the corresponding authors who decide how to share it with their coauthors. Last year’s winners were William J. Karpus and Kevin J. Kennedy for "MIP-1 and MCP-1 differentially regulate acute and relapsing autoimmune encephalomyelitis as well as Th1/Th2 lymphocyte differentiation" (J. Leukoc. Biol. 62, 681–687, 1997). For the year 2002, the most cited research paper with 71 citations from 1997 through 2001 was by E. Manickan, S. Kanangat, R. J. Rouse, Z. Yu, and B. T. Rouse, entitled "Enhancement of immune response to naked DNA vaccine by immunization with transfected dendritic cells" (J. Leukoc. Biol. 61, 125–132, 1997).

Dr. Barry Rouse and a high school graduate Smita Nair initiated studies of dendritic cells (DC) in the 1980s long before they became readily produced in in vitro cultures. His laboratory demonstrated in a pioneering study that DC produce interleukin-12 (J. Leukoc. Biol. 57, 310–316, 1995). Unfortunately, he said, that observation was so ahead of its time that they themselves failed to realize its importance. The winning paper, although also ahead of its time, represents a straightforward study showing that vaccination of mice with DC transfected to express herpes immunogens yielded a better immune response than vaccination with transfected macrophages. This approach also resulted in greater resistance to herpes challenge than just vaccinating with plasmid DNA encoding the herpes proteins.

Dr. Rouse is currently the Lindsay Young Distinguished Professor of Microbiology at the University of Tennessee (Memphis). He has devoted his career to studies of the immunobiology of herpes virus infections ever since his days as a postdoctoral fellow from 1970 to 1972 at the Walter and Eliza Hall in Melbourne, Australia. He continues to be ahead of the crowd by currently studying the proangiogenic consequences of herpes infection of the eye. The first author of the most cited paper, Dr. Elan Manicken is currently a scientist at Wyeth Pharm (Madison, NJ). The second author, Dr. Siva Kanangut, who performed the quantitative reverse transcriptase-polymerase chain reaction, is currently at the University of Tennessee. Although his son Richard J. Rouse was phenomenally good at isolating DC for the study and remains a dedicated scientist, he is now in the process of becoming a patent lawyer. Dr. Z. Y. Yu also contributed to the research by generating herpes plasmids and is currently at the National Cancer Institute (Bethesda, MD) in Dr. Steven Rosenberg’s laboratory. Dr. Rouse continues to mentor numerous excellent young scientists who have subsequently gone on to develop excellent scientific careers at various institutes and centers.

We also honor the five next-most cited research articles from 1997 to 2001 with 50–47 citations:

• 1 White, J. R., Imburgia, C., Dul, E., Appelbaum, E., O’Donnell, K., O’Shannessy, D.J., Brawner, M., Fornwald, J., Adamou, J., Elshourbagy, N. A., Kaiser, K., Foley, J. J., Schmidt, D. B., Johanson, K., Macphee, C., Moores, K., McNulty, D., Scott, G. F., Schleimer, R. P., Sarau, H. M. (1997) Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils. J. Leukoc. Biol. 62,667-675[Abstract]
  
• 2 Annunziato, F., Cosmi, L., Galli, G., Beltrame, C., Romagnani, P., Manetti, R., Romagnani, S., Maggi, E. (1999) Assessment of chemokine receptor expression by human Th1 and Th2 cells in vitro and in vivo. J. Leukoc. Biol. 65,691-699[Abstract]
  
• 3 D’Elios, M. M., Romagnani, P., Scaletti, C., Annunziato, F., Manghetti, M., Mavilia, S., Parronchi, P., Pupilli, C., Pizzolo, G., Maggi, E., Del Prete, G. F., Romagnani, S. (1997) In vivo CD30 expression in human diseases with predominant activation of Th2-like T cells. J. Leukoc. Biol. 61,539-544[Abstract]
  
• 4 Carols, T. M., Clark, R. S., Franicola-Higgins, D., Schiding, J. K., Kochanek, P. M. (1997) Expression of endothelial adhesion molecules and recruitment of neutrophils after traumatic brain injury in rats. J. Leukoc. Biol. 61,279-285[Abstract]
  
• 5 Eigler, A., Siegmund, B., Emmerich, U., Baumann, K. H., Hartmann, G., Endres, S. (1998) Anti-inflammatory activities of cAMP-elevating agents: enhancement of IL-10 synthesis and concurrent suppression of TNF production. J. Leukoc. Biol. 63,101-107[Abstract]
  

The award-winning review article, entitled "MIG and IP10: CXC chemokines that target lymphocytes" (J. Leukoc. Biol. 61, 246–257, 1997), was authored by Dr. Joshua M. Farber. Dr. Farber, as a postdoctoral fellow in Dr. Daniel Nathans’ laboratory at Johns Hopkins University (Baltimore, MD), initiated studies of genes activated in mouse macrophages by lymphokine-containing culture supernatants from concanavalin A-stimulated splenocytes, which led to his identifying 11 highly expressed genes. From the cDNA sequences, Dr. Farber recognized that two of these genes encoded members of the emerging family of C-X-C chemotactic cytokines, which he named Mig and Crg-2, the latter being the murine ortholog of interferon (IFN)-inducible protein 10 (IP-10).

He published the initial identification and characterization of these chemokine genes in 1990. Dr. Farber chose to focus on chemokines because as secreted factors, they and/or their receptor(s) might be therapeutic agents or targets and because the potent induction of these two chemokines by IFN- suggested that they might play important roles in host defense and inflammation. Dr. Farber has continued his studies of these two CXCR3 ligands as well as other chemokines and their receptors over the past decade because of the chemokines’ pivotal roles in immunity and in diseases as diverse as AIDS and atherosclerosis. He is currently a senior investigator in the Laboratory of Clinical Investigation at the National Institute of Allergy and Infectious Diseases, National Institutes of Health (Bethesda, MD). The winning review of Mig/CXCL9 and IP-10/CXCL10 was written in response to an invitation from our Associate Editor Dr. Craig Reynolds.

The five runners-up in the review category for 1997–2001 with 121–69 citations were as follows: 6 Savill, J. (1997) Apoptosis in resolution of inflammation. J. Leukoc. Biol. 61,375-380[Abstract] 7 Darnay, B. G., Aggarwal, B. B. (1997) Early events of TNF signaling: a story of associations and dissociations J. Leukoc. Biol. 61,559-566[Abstract] 8 Fenton, M. J., Golenbock, D. T. (1998) LPS-binding proteins and receptors. J. Leukoc. Biol. 64,25-32[Abstract] 9 Yoshi, O., Imai, T., Nomiyama, H. (1997) Novel lymphocyte-specific CC chemokines and their receptors. J. Leukoc. Biol. 62,634-644[Abstract] 10 Kim, C. H., Broxmeyer, H. E. (1999) Chemokines: signal lamps of trafficking of T and B cells for development and effector function. J. Leukoc. Biol. 65,6-15[Abstract]

It should be noted that three of the five most highly cited reviews were actually invited overviews based on meeting presentations, supporting the merit of contributing such an article for publication in the Journal of Leukocyte Biology.

Related Articles

Assessment of chemokine receptor expression by human Th1 and Th2 cells in vitro and in vivo

F Annunziato, L Cosmi, G Galli, C Beltrame, P Romagnani, R Manetti, S Romagnani, and E Maggi
J. Leukoc. Biol. 1999 65: 691-699. [Abstract] [PDF]

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