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A more recent version of this article appeared on October 1, 2008

Published online before print May 30, 2008
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© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.1107774

Received for publication November 18, 2007.
Revised March 10, 2008.
Accepted for publication March 11, 2008.

Article

Immune-mediated dormancy: an equilibrium with cancer

Michele W. L. Teng *, Jeremy B. Swann *, Catherine M. Koebel {dagger}, Robert D. Schreiber {dagger}, and Mark J. Smyth *@

*Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia; and {dagger}Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA

@ To whom correspondence should be addressed. E-mail: mark.smyth{at}petermac.org.


  Abstract

This brief review discusses the role of the immune system in tumor development, covering a brief history of cancer immunity and a summary of the concept of cancer immunoediting, including its three phases: elimination, equilibrium, and escape. The latter half of this review then focuses specifically on the equilibrium phase, making note of previous work, suggesting that immunity might maintain cancer in a dormant state, and concluding with a description of a tractable mouse model unequivocally demonstrating that immunity can indeed hold preformed cancer in check. These findings form a framework for future studies aimed at validating immune-mediated cancer dormancy in humans with the hopes of devising new, immunotherapeutic strategies to treat established cancer.

Key Words: immunoediting • elimination • escape






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