Accuri C6 Flow Cytometer System
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Published online before print May 21, 2008
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© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.1107770

Received for publication November 18, 2007.
Revised March 19, 2008.
Accepted for publication April 16, 2008.

Article

T cells with regulatory activity in hepatitis C virus infection: what we know and what we don’t

Angela Dolganiuc @ and Gyongyi Szabo

Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA

@ To whom correspondence should be addressed. E-mail: angela.dolganiuc{at}umassmed.edu.


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Abstract

The mechanism behind the apparent lack of effective antiviral immune response in patients with chronic hepatitis C virus (HCV) infection is poorly understood. Although multiple levels of abnormalities have been identified in innate and adaptive immunity, it remains unclear if any of the subpopulations of T cells with regulatory capacity (Tregs) contribute to the induction and maintenance of HCV persistence. In this review, we summarize the current knowledge about Tregs as they relate to HCV infection.

Key Words: Tr1 • Th3 • CD8+ Tregs • FoxP3 • IL-10 • TGF-{beta} • liver