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Published online before print May 12, 2006

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© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.1105672

Received for publication November 17, 2005.
Revised March 21, 2006.
Accepted for publication March 24, 2006.

Article

New insights into the regulation of TLR signaling

School of Biochemistry and Immunology, Trinity College Dublin, Ireland

^@ To whom correspondence should be addressed. E-mail: miggins{at}tcd.ie.

	Abstract

Toll-like receptor (TLR) activation is dictated by a number of factors including the ligand itself and the localization of the receptor, in terms of expression profile and subcellular localization and the signal transduction pathway that has been activated. Recent work into TLR signal transduction has revealed complex regulation at a number of different levels including regulation by phosphorylation, targeted degradation, and sequestration of signaling molecules. Here, we describe recent advances that have been made in our understanding of how TLR signaling is regulated at the biochemical level.

Key Words: inflammation • regulatory molecules

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