Journal of Leukocyte Biology BioLegend: Treg, Th17, Stem Cell
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on March 1, 2006

Published online before print December 19, 2005
This Article
Right arrow Full Text (Reprint (PDF))
Right arrow All Versions of this Article:
jlb.0905537v1
79/3/417    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bhat, R.
Right arrow Articles by Watzl, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bhat, R.
Right arrow Articles by Watzl, C.
© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.0905537

Received for publication September 29, 2005.
Revised November 25, 2005.
Accepted for publication November 26, 2005.

Article

Fine-tuning of immune responses by SLAM-related receptors

Rauf Bhat , Philipp Eissmann , Johanna Endt , Sabrina Hoffmann , and Carsten Watzl @

Institute for Immunology, University Heidelberg, Germany

@ To whom correspondence should be addressed. E-mail: carsten.watzl{at}urz.uni-heidelberg.de.


  Abstract

The modulation of antigen receptor signals is important for a productive immune response. The main function of the recently identified members of the signaling lymphocyte activating molecule (SLAM)-related receptors (SRR) is the fine-tuning of immune cell activation. Disruption of SRR function is the cause for severe immune disorders such as X-linked lymphoproliferative syndrome (XLP), where XLP patients carry a mutation in SLAM-associated protein (SH2D1A), an important adaptor molecule for the signal transduction of SRR. Recent data also suggest that SRR may play a role in autoimmune diseases and the function of hematopoietic stem and progenitor cells. Here, we review the current understanding of SRR function in different immune cells.

Key Words: T cells • NK cells • activation • costimulation • Th1/2 polarization




This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
E. D. Hsi, R. Steinle, B. Balasa, S. Szmania, A. Draksharapu, B. P. Shum, M. Huseni, D. Powers, A. Nanisetti, Y. Zhang, et al.
CS1, a Potential New Therapeutic Antibody Target for the Treatment of Multiple Myeloma
Clin. Cancer Res., May 1, 2008; 14(9): 2775 - 2784.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. C. Hoffmann, C. Schellack, S. Textor, S. Konold, D. Schmitz, A. Cerwenka, S. Pflanz, and C. Watzl
Identification of CLEC12B, an Inhibitory Receptor on Myeloid Cells
J. Biol. Chem., August 3, 2007; 282(31): 22370 - 22375.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. Eissmann and C. Watzl
Molecular Analysis of NTB-A Signaling: A Role for EAT-2 in NTB-A-Mediated Activation of Human NK Cells.
J. Immunol., September 1, 2006; 177(5): 3170 - 3177.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Copyright © 2005 by the Society for Leukocyte Biology.