HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

Published online before print October 3, 2007

This Article Full Text (Reprint (PDF)) All Versions of this Article: jlb.0607371v1 83/3/523    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Venet, F. Articles by Ayala, A. Search for Related Content PubMed PubMed Citation Articles by Venet, F. Articles by Ayala, A.

© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.0607371

Received for publication June 9, 2007.
Revised August 24, 2007.
Accepted for publication September 8, 2007.

Article

Regulatory T cell populations in sepsis and trauma

Fabienne Venet ^*, Chun-Shiang Chung ^*, Guillaume Monneret , Xin Huang ^*, Brian Horner ^*, Megan Garber ^*, and Alfred Ayala ^*@

*Division of Surgical Research, Rhode Island Hospital/Brown University, Providence, Rhode Island, USA; and Hospices Civils de Lyon, Immunology Laboratory, Hopital Neurologique, Bron, France

^@ To whom correspondence should be addressed. E-mail: AAyala{at}Lifespan.org.

	Abstract

Sepsis syndrome remains the leading cause of mortality in intensive care units. It is now believed that along with the body’s hyperinflammatory response designated to eliminate the underlying pathogen, mechanisms are initiated to control this initial response, which can become deleterious and result in immune dysfunctions and death. A similar state of immune suppression has been described after numerous forms of severe trauma/injury. Although the evidence for immune dysfunctions after sepsis has grown, much remains to be understood about mechanisms underpinning its development and how it acts to increase the morbid state of the critically ill patient. In this context, although the majority of clinical and basic science conducted so far has focused on the roles of myeloid cell populations, the contribution of T lymphocytes and in particular, of regulatory T cells has been somewhat ignored. The studies presented here support the concept that regulatory T lymphocytes (CD4+CD25+ regulatory, , and NK T cells) play a role in the control of immune responses and are affected by injury and sepsis. This may be related to their capacity to interact with components of the innate and adaptive immune responses and to their ability to be activated nonspecifically by bacterial products and/or cytokines and to regulate through direct cell–cell and/or soluble mediators. It is our hope that a better understanding of the mechanism through which those rare lymphocyte subsets exert such a profound effect on the immune response may help in improving our ability not only to diagnose but also to treat the critically ill individual.

Key Words: CD4+CD25+ • NKT cells • T cells • lymphocyte • severe injury

This article has been cited by other articles:

				M. M. Wurfel, A. C. Gordon, T. D. Holden, F. Radella, J. Strout, O. Kajikawa, J. T. Ruzinski, G. Rona, R. A. Black, S. Stratton, et al. Toll-like Receptor 1 Polymorphisms Affect Innate Immune Responses and Outcomes in Sepsis Am. J. Respir. Crit. Care Med., October 1, 2008; 178(7): 710 - 720. [Abstract] [Full Text] [PDF]