Accuri C6 Flow Cytometer System
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© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.0607338

Received for publication June 1, 2007.
Revised July 19, 2007.
Accepted for publication July 20, 2007.

Article

Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation

Philippe Van Lint and Claude Libert @

Departments of Molecular Biomedical Research, VIB, and Molecular Biology, Ghent University, Ghent, Belgium

@ To whom correspondence should be addressed. E-mail: Claude.Libert{at}dmbr.Ugent.be.


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Abstract

The action of matrix metalloproteinases (MMPs) was originally believed to be restricted to degradation of the extracellular matrix; however, in recent years, it has become evident that these proteases can modify many nonmatrix substrates, such as cytokines and chemokines. The use of MMP-deficient animals has revealed that these proteases can indeed influence the progression of various inflammatory processes. This review aims to provide the reader with a concise overview of these novel MMP functions in relation to leukocyte migration.

Key Words: extracellular matrix • ELR




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