Journal of Leukocyte Biology Myeloid cells, immune suppression, tumor immunology
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A more recent version of this article appeared on October 1, 2006

Published online before print August 2, 2006
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© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.0506312


Received for publication May 9, 2006.
Revised July 7, 2006.
Accepted for publication July 16, 2006.


Article

Cellular reprogramming by gram-positive bacterial components: a review

Julliette M. Buckley , Jiang Huai Wang @, and H. Paul Redmond

Department of Academic Surgery, Cork University Hospital, National University of Ireland (NUI)/University College Cork (UCC)

@ To whom correspondence should be addressed. E-mail: jh.wang{at}ucc.ie.


   Abstract

LPS tolerance has been the focus of extensive scientific and clinical research over the last several decades in an attempt to elucidate the sequence of changes that occur at a molecular level in tolerized cells. Tolerance to components of gram-positive bacterial cell walls such as bacterial lipoprotein and lipoteichoic acid is a much lesser studied, although equally important, phenomenon. This review will focus on cellular reprogramming by gram-positive bacterial components and examines the alterations in cell surface receptor expression, changes in intracellular signaling, gene expression and cytokine production, and the phenomenon of cross-tolerance.

Key Words: lipoprotein • lipopolysaccharide • tolerance • cross-tolerance • TLR signaling




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