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A more recent version of this article appeared on January 1, 2006

Published online before print October 21, 2005
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© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.0505286

Received for publication May 31, 2005.

Accepted for publication August 22, 2005.

Article

Activation of human eosinophils via P2 receptors: novel findings and future perspectives

Davide Ferrari *@, Andrea la Sala {dagger}, Elisabeth Panther {ddagger}, Johannes Norgauer {sect}, Francesco Di Virgilio *, and Marco Idzko {ddagger}

*Department of Experimental and Diagnostic Medicine, Section of General Pathology and Interdisciplinary Center for the Study of Inflammation (ICSI), University of Ferrara, Italy; {dagger}Laboratory of Molecular and Cellular Biology, IRCCS, San Raffaele, Rome, Italy; {ddagger}Department of Gastroenterology, University of Freiburg, Germany; and {sect}Department of Dermatology, University of Jena, Germany

@ To whom correspondence should be addressed. E-mail: dfr{at}unife.it.


  Abstract

A growing body of information indicates that release of intracellular nucleotides represents an important way to modulate several cell pathways in physiological or pathological conditions. Nucleotides released as a consequence of cell damage, cell stress, bacterial infection, or other noxious stimuli signal at a class of plasma membrane receptors--P2 receptors--activating diverse intracellular pathways in many tissues and organs. For example, nucleotides secreted in the airway system control chloride/liquid secretion, goblet cell degranulation, and ciliary beat frequency. Several studies indicate that nucleotides play a role in airway diseases through their action on multiple cell types, including mast cells, dendritic cells, neurons, and eosinophils. Recent work by us and other groups led to the identification and characterization of P2 receptors expressed by human eosinophils. In this review, we will summarize recent developments in this field and put forward a hypothesis about the role of P2 receptors in pathophysiological conditions where eosinophils are major players.

Key Words: extracellular nucleotides • inflammation






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