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Published online before print October 4, 2005

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© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.0505244

Received for publication May 6, 2005.
Revised June 28, 2005.
Accepted for publication July 15, 2005.

Article

Distribution and leukocyte contacts of T cells in the lung

J. M. Wands ^*, Christina L. Roark ^*, M. Kemal Aydintug ^*, Niyun Jin ^*, Youn-Soo Hahn , Laura Cook ^*, Xiang Yin ^*, Joe Dalporto ^*, Michael Lahn ^*, Dallas M. Hyde , Erwin W. Gelfand , Robert J. Mason ^¶, Rebecca L. O’Brien ^*, and Willi K. Born ^*@

Departments of *Immunology, Pediatrics, Division of Cell Biology, and ^¶Medicine, National Jewish Medical and Research Center, Denver, Colorado; Department of Pediatrics, Chungbuk National University and College of Medicine, Cheongju, Korea; and California National Primate Research Center, University of California, Davis

^@ To whom correspondence should be addressed. E-mail: bornw{at}njc.org.

	Abstract

Pulmonary T cells protect the lung and its functions, but little is known about their distribution in this organ and their relationship to other pulmonary cells. We now show that and T cells are distributed differently in the normal mouse lung. The T cells have a bias for nonalveolar locations, with the exception of the airway mucosa. Subsets of T cells exhibit further variation in their tissue localization. and T cells frequently contact other leukocytes, but they favor different cell-types. The T cells show an intrinsic preference for F4/80⁺ and major histocompatibility complex class II⁺ leukocytes. Leukocytes expressing these markers include macrophages and dendritic cells, known to function as sentinels of airways and lung tissues. The continuous interaction of T cells with these sentinels likely is related to their protective role.

Key Words: T cell receptor • T cell subsets • mouse

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