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A more recent version of this article appeared on February 1, 2004

Published online before print October 13, 2003
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© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.0503245

Received for publication May 28, 2003.
Revised August 20, 2003.
Accepted for publication August 22, 2003.

Article

Physiologic variations in granulocytic surface antigen expression: impact of age, gender, pregnancy, race, and stress

M. Tarek Elghetany *@ and Francis Lacombe {dagger}

*Division of Hematopathology, Department of Pathology, University of Texas Medical Branch, Galveston; and {dagger}Laboratory Hematology, Hospital Haut-Lévêque, CHU Bordeaux, France

@ To whom correspondence should be addressed. E-mail: melgheta{at} utmb.edu.


  Abstract

There is a growing interest in the use of granulocytic surface markers for the diagnosis of some inherited and acquired disorders, such as Shwachman-Diamond syndrome and myelodysplastic syndromes. Understanding the impact of physiologic factors, such as age, gender, pregnancy, race, and stress on granulocytic surface markers is essential for appropriate interpretation of results. Some surface markers show marked variations at the very early and the very late stages in life. Fetal granulocytes tend to have a lower expression of CD11b, CD11c, CD18, and CD32. Term neonatal granulocytes are frequently associated with a lower expression of CD10, CD11b, CD13, CD33, and CD62L and a higher expression of CD55 and CD64. Elderly individuals have shown a higher expression of CD64. Pregnancy is associated with temporary changes in granulocytic surface markers, such as a lower expression of CD16 and a higher CD64, partially mimicking an inflammatory response. Stress also has an impact on some surface markers, particularly adhesion molecules, such as CD62L and CD54. These factors need to be taken in consideration for the optimal interpretation of granulocytic surface marker studies.

Key Words: flow cytometry • neonates • aging






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