Vancouver
A more recent version of this article appeared on October 1, 2008

Published online before print July 29, 2008
This Article
Right arrow Full Text (Reprint (PDF))
Right arrow All Versions of this Article:
jlb.0408256v1
84/4/1039    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Burt, B. M.
Right arrow Articles by DeMatteo, R. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Burt, B. M.
Right arrow Articles by DeMatteo, R. P.
© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.0408256

Received for publication April 22, 2008.
Revised June 17, 2008.
Accepted for publication July 2, 2008.

Article

CD11c identifies a subset of murine liver natural killer cells that responds to adenoviral hepatitis

Bryan M. Burt , George Plitas , Jennifer A. Stableford , Hoang M. Nguyen , Zubin M. Bamboat , Venu G. Pillarisetty , and Ronald P. DeMatteo @

Hepatobiliary Service, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

@ To whom correspondence should be addressed. E-mail: dematter{at}mskcc.org.


arrow
Abstract

The liver contains a unique repertoire of immune cells and a particular abundance of NK cells. We have found that CD11c defines a distinct subset of NK cells (NK1.1+CD3–) in the murine liver whose function was currently unknown. In naïve animals, CD11c+ liver NK cells displayed an activated phenotype and possessed enhanced effector functions when compared with CD11c– liver NK cells. During the innate response to adenovirus infection, CD11c+ NK cells were the more common IFN-{gamma}-producing NK cells in the liver, demonstrated enhanced lytic capability, and gained a modest degree of APC function. The mechanism of IFN-{gamma} production in vivo depended on TLR9 ligation as well as IL-12 and -18. Taken together, our findings demonstrate that CD11c+ NK cells are a unique subset of NK cells in the murine liver that contribute to the defense against adenoviral hepatitis.

Key Words: IFN-{gamma} • adenovirus • dendritic cells • Toll-like receptor 9 • hepatic




This article has been cited by other articles:


Home page
 J. Leukoc. Biol.Home page
B. Gao, S. Radaeva, and O. Park
Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases
J. Leukoc. Biol., September 1, 2009; 86(3): 513 - 528.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
J.-H. Choi, Y. Do, C. Cheong, H. Koh, S. B. Boscardin, Y.-S. Oh, L. Bozzacco, C. Trumpfheller, C. G. Park, and R. M. Steinman
Identification of antigen-presenting dendritic cells in mouse aorta and cardiac valves
J. Exp. Med., March 16, 2009; 206(3): 497 - 505.
[Abstract] [Full Text] [PDF]