Journal of Leukocyte Biology
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A more recent version of this article appeared on March 1, 2008

Published online before print December 13, 2007
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© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.0407215

Received for publication April 9, 2007.
Revised November 1, 2007.
Accepted for publication November 15, 2007.

Article

Loss of function in virus-specific lung effector T cells is independent of infection

Subhashini Arimilli , Ellen M. Palmer , and Martha A. Alexander-Miller @

Department of Microbiology & Immunology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA

@ To whom correspondence should be addressed. E-mail: marthaam{at}wfubmc.edu.


  Abstract

Recently, several studies, including those with respiratory syncytial virus, mouse pneumovirus, and simian virus 5, have reported that virus-specific CD8+ effector cells entering the lung as a result of respiratory infection undergo significant loss of function. The impaired function in these cells has been proposed to be the result of infection-induced changes in the lung. Although virus-specific effects may contribute to regulation of T cells in the lung, the findings from this study provide evidence that the basal lung environment is sufficient to promote loss of function in effector cells. Loss of function occurs within 48 h of entry into the lung and is most evident in cells residing in the lung parenchyma. These findings suggest an additional paradigm for the immunoregulation of effector cells that enter the lung as a result of virus infection.

Key Words: CTL • regulation • CD8 • respiratory tract




This article has been cited by other articles:


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R. B. Fulton, M. R. Olson, and S. M. Varga
Regulation of Cytokine Production by Virus-Specific CD8 T Cells in the Lungs
J. Virol., August 15, 2008; 82(16): 7799 - 7811.
[Abstract] [Full Text] [PDF]


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Copyright © 2007 by the Society for Leukocyte Biology.