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Published online before print July 15, 2003

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© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.0403150

Received for publication April 14, 2003.
Revised May 30, 2003.
Accepted for publication May 30, 2003.

Article

Antimicrobial polypeptides

David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1690

^@ To whom correspondence should be addressed. E-mail: tganz{at}mednet.ucla.edu.

	Abstract

The respiratory tract presents a large and potentially vulnerable surface to inhaled microbes. It is coated by a thin layer of secretions generated by airway epithelial cells, submucosal glands, resident and recruited phagocytes (neutrophils, eosinophils, monocytes, and macrophages) and alveolar epithelial cells, as well as substances that enter from blood plasma. More than 80 years ago, Alexander Fleming observed that respiratory secretions have microbicidal and microbistatic properties [1]. He described the activity of lysozyme, one of the principal polypeptides of these secretions. Since then, a number of additional antimicrobial components have been identified, and there is increasing insight into their complex interactions. This review is an update of my previous summary of this area [2].

Key Words: innate immunity • host defense • lysozyme • defensins • lactoferrin • secretory leukoprotease inhibitor

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