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A more recent version of this article appeared on January 1, 2008

Published online before print September 28, 2007
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© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.0307137

Received for publication March 5, 2007.
Revised July 19, 2007.
Accepted for publication September 5, 2007.

Article

A regulatory role of interleukin 15 in wound healing and mucosal infection in mice

Yoshiko Kagimoto *{dagger}, Hisakata Yamada *, Takahiro Ishikawa *, Naoyoshi Maeda {ddagger}, Fumi Goshima {sect}, Yukihiro Nishiyama {sect}, Masutaka Furue {dagger}, and Yasunobu Yoshikai *@

*Division of Host Defense, Medical Institute of Bioregulation, {dagger}Department of Dermatology, Graduate School of Medicine, {ddagger}Degital Medicine Initiative, Kyushu University, Fukuoka, Japan; and {sect}Department of Virology, Nagoya University School of Medicine, Nagoya, Japan

@ To whom correspondence should be addressed. E-mail: yoshikai{at}bioreg.kyushu-u.ac.jp.


  Abstract

IL-15 plays a critical role in the development and maturation of {gamma}{delta} intraepithelial T lymphocytes (IEL), which are known to play important roles in wound healing and resolving inflammation in mice. In this study, we found that IL-15 transgenic (Tg) mice, under the control of a MHC Class I promoter, exhibited accelerated wound healing but were highly susceptible to genital infection with HSV-2. The IEL in the skin and reproductive organs of IL-15 Tg mice produced an aberrantly higher level of TGF-{beta}1 upon TCR triggering than in control mice. In vivo neutralization of TGF-{beta} ameliorated the susceptibility of IL-15 Tg mice to genital HSV-2 infection. Taken together, overexpression of IL-15 may stimulate IEL to produce TGF-{beta}1, promoting wound healing but impeding protection against genital HSV-2 infection.

Key Words: {gamma}{delta} T cells • immunity • immune regulation • cytokines






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Copyright © 2007 by the Society for Leukocyte Biology.