Journal of Leukocyte Biology Myeloid cells, immune suppression, tumor immunology
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A more recent version of this article appeared on February 1, 2007

Published online before print August 17, 2006
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© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.0306194

Received for publication March 13, 2006.
Revised April 18, 2006.
Accepted for publication May 9, 2006.

Article

Pivotal Advance: Exposure to LPS suppresses CD4 T cell cytokine production in Salmonella-infected mice and exacerbates murine typhoid

Aparna Srinivasan and Stephen J. McSorley @

Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, and Center for Infectious Diseases and Translational Microbiology Research, University of Minnesota Medical School, McGuire Translational Research Facility, Minneapolis

@ To whom correspondence should be addressed. E-mail: mcsor002{at}umn.edu.


  Abstract

A number of studies have documented suppression of lymphocyte activation in mice infected with Salmonella. Here, we describe incomplete activation of CD4+ T cells following intravenous injection of specific peptide and LPS into Salmonella-infected mice. Although antigen-specific CD4+ T cells were activated by peptide/LPS to increase surface CD69 expression, they did not produce IL-2 or TNF-{alpha}. Suppression of cytokine production did not require prolonged exposure of the T cells to the Salmonella-infected environment, was not antigen specific, but was dependent upon the presence of LPS during stimulation. These data suggest that Salmonella-infected mice are exquisitely sensitive to the generation of a suppressive environment following innate immune stimulation with LPS. In agreement with this interpretation, repeated low-dose administration of LPS caused uncontrolled replication of attenuated Salmonella in vivo.

Key Words: bacterial infection • IL-2 • tumor necrosis factor-{alpha}


Related Article

Interview with Dr. Stephen J. McSorley and Ms. Aparna Srinivasan regarding Pivotal Advance: Secondary exposure to LPS suppresses CD4+ T cells and exacerbates murine typhoid
Helene F. Rosenberg
J. Leukoc. Biol. 2007 81: 401-402. [Full Text] [PDF]





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Copyright © 2006 by the Society for Leukocyte Biology.