HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

Published online before print May 17, 2006

This Article Full Text (Reprint (PDF)) All Versions of this Article: jlb.0306190v1 80/2/376    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Corsini, E. Articles by Racchi, M. Search for Related Content PubMed PubMed Citation Articles by Corsini, E. Articles by Racchi, M.

© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.0306190

Received for publication March 13, 2006.
Revised April 9, 2006.
Accepted for publication April 10, 2006.

Article

High interleukin-10 production is associated with low antibody response to influenza vaccination in the elderly

Emanuela Corsini ^*@, Luigi Vismara , Laura Lucchi ^*, Barbara Viviani ^*, Stefano Govoni , Corrado L. Galli ^*, Marina Marinovich ^*, and Marco Racchi

*Laboratory of Toxicology, Department of Pharmacological Sciences, University of Milan, Italy; and Department of Experimental and Applied Pharmacology, University of Pavia, Italy

^@ To whom correspondence should be addressed. E-mail: emanuela.corsini{at}unimi.it.

	Abstract

The present study was designed to determine the correlation among dehydroepiandrosterone (DHEA), cortisol plasma levels, and immune functionality at the time of vaccination with antibody response to influenza vaccination in young and old, healthy volunteers. Fifty-two elderly subjects, ages 63-85 years, and 14 young subjects, ages 26-41 years, entered the study. Plasma levels of DHEA and cortisol and in vitro cytokine production in response to lipopolysaccharide (LPS) and phytohaemagglutinin (PHA) by peripheral blood leukocytes were assessed at the time of vaccination, and antibody titer was measured before and 18 days after influenza virus vaccination. Elderly subjects were characterized by an increase in the cortisol:DHEA ratio, mainly as a result of a decrease in DHEA. A decrease in LPS-induced tumor necrosis factor (TNF-), increased PHA-induced interleukin-10 (IL-10) release, and similar PHA-induced interferon- production were observed in elderly subjects compared with young volunteers. Lower antibody titer to influenza A virus was observed in elderly individuals, and the seroconversion factor was found to be correlated inversely with IL-10 production and correlated directly with TNF- production and to a lesser extent, with the plasma level of DHEA. These results suggest that altered cytokine production in elderly subjects at the moment of vaccination can be predictive of a low response to influenza vaccination and warrant the study of strategies to improve protection afforded by the use of vaccines.

Key Words: immunosenescence • cytokines • dehydroepiandrosterone • aging

This article has been cited by other articles:

				H. M. Kim, Y.-W. Lee, K.-J. Lee, H. S. Kim, S. W. Cho, N. van Rooijen, Y. Guan, and S. H. Seo Alveolar Macrophages Are Indispensable for Controlling Influenza Viruses in Lungs of Pigs J. Virol., May 1, 2008; 82(9): 4265 - 4274. [Abstract] [Full Text] [PDF]

				J. Li, L. G. Cowden, J. D. King, D. A. Briles, H. W. Schroeder Jr, A. B. Stevens, R. T. Perry, Z. Chen, M. S. Simmons, H. W. Wiener, et al. Effects of Chronic Stress and Interleukin-10 Gene Polymorphisms on Antibody Response to Tetanus Vaccine in Family Caregivers of Patients With Alzheimer's Disease Psychosom Med, July 1, 2007; 69(6): 551 - 559. [Abstract] [Full Text] [PDF]

				K. T. Keylock, T. Lowder, K. A. Leifheit, M. Cook, R. A. Mariani, K. Ross, K. Kim, K. Chapman-Novakofski, E. McAuley, and J. A. Woods Higher antibody, but not cell-mediated, responses to vaccination in high physically fit elderly J Appl Physiol, March 1, 2007; 102(3): 1090 - 1098. [Abstract] [Full Text] [PDF]