Journal of Leukocyte Biology
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Published online before print August 21, 2006
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© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.0306158

Received for publication March 4, 2006.
Revised April 12, 2006.
Accepted for publication May 17, 2006.

Article

HIV interactions with dendritic cells: has our focus been too narrow?

Heather Donaghy , John Wilkinson , and Anthony L Cunningham @

Centre for Virus Research, Westmead Millennium Institute, Sydney, New South Wales, Australia

@ To whom correspondence should be addressed. E-mail: tony_cunningham{at}wmi.usyd.edu.au.


  Abstract

Although few in number, dendritic cells (DC) are heterogeneous, ubiquitous, and are crucial for protection against pathogens. In this review, the different DC subpopulations have been described and aspects of DC biology are discussed. DC are important, not only in the pathogenesis of HIV, but also in the generation of anti-HIV immune responses. This review describes the roles that DC are thought to play in HIV pathogenesis, including uptake and transport of virus. We have also discussed the effects that the virus exerts on DC such as infection and dysfunction. Then we proceed to focus on DC subsets in different organs and show how widespread the effects of HIV are on DC populations, It is clear that the small number of studies on tissue-derived DC limits current research into the pathogenesis of HIV.

Key Words: pathogenesis • immune responses




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