HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

Published online before print October 2, 2003

This Article Full Text (Reprint (PDF)) All Versions of this Article: jlb.0303089v1 74/6/971    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Hoyne, G. F. Search for Related Content PubMed PubMed Citation Articles by Hoyne, G. F.

© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.0303089

Received for publication March 2, 2003.
Revised July 21, 2003.
Accepted for publication July 22, 2003.

Article

Notch signaling in the immune system

ACRF Genetics Laboratory and Medical Genome Centre, John Curtin School of Medical Research, Australian National University, Canberra

^@ To whom correspondence should be addressed. E-mail: Gerard.Hoyne{at} anu.edu.au.

	Abstract

Notch signaling plays a preeminent role during development in not only regulating cell fate decisions, but it can also influence growth and survival of progenitor cells. In the immune system, Notch is required for the maintenance of hematopoietic stem cells and in directing T- versus B-lineage commitment. In this review, I will summarize some of the recent findings relating to the function of Notch in the immune system during lymphocyte development and in the generation and function of mature cells.

Key Words: development • haematopoiesis • lymphopoiesis • lymphocytes