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Published online before print March 30, 2007

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© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.0207109

Received for publication February 13, 2007.
Revised March 25, 2007.
Accepted for publication March 25, 2007.

Article

Rapid transit in the immune cells: the role of mRNA turnover regulation

Program in BioMolecular Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

^@ To whom correspondence should be addressed. E-mail: khabar{at}kfshrc.edu.sa.

	Abstract

There have been recent, significant advances about the role of mRNA turnover in controlling gene expression in immune cells. Post-transcriptional regulation of gene expression contributes to the characteristics of many of the processes underlying the immune response by ensuring early, rapid, and transient action. The emphasis of this review is on current work that deals with the regulation of mRNA decay during innate immunity against microbes and T cell activation as a model of the adaptive response.

Key Words: mRNA stability • post-trancriptional regulation • cytokines