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Published online before print June 12, 2006

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© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.0206123

Received for publication February 28, 2006.
Revised April 11, 2006.
Accepted for publication April 13, 2006.

Article

The central role of adrenomedullin in host defense

Cell and Cancer Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

^@ To whom correspondence should be addressed. E-mail: zudairee{at}mail.nih.gov.

	Abstract

Thirteen years after the isolation of adrenomedullin (AM) from a human pheochromocytoma, the literature is awash with reports describing its implication in countless physiological and disease mechanisms ranging from vasodilatation to cancer promotion. A growing body of evidence illustrates AM as a pivotal component in normal physiology and disease with marked beneficial effects in the host defense mechanism. Exogenous administration of AM as well as its ectopic overexpression and the use of drugs, which potentiates its activity, are promising strategies for treatment of septic shock and several other pathogen-related disorders. Although major progress toward this end has been achieved over the past few years, our further understanding of the pleiotropic mechanisms involved in AM as a protective peptide is paramount to maximize its clinical relevance.

Key Words: PAMP • AMBP-1 • septic shock

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