Journal of Leukocyte Biology Myeloid cells, immune suppression, tumor immunology
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Published online before print May 9, 2006
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© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.0206118

Received for publication February 27, 2006.
Revised March 26, 2006.
Accepted for publication March 27, 2006.

Article

The generation and modulation of antigen-specific memory CD8 T cell responses

Ali Jabbari * and John T. Harty *{dagger}@

*Interdisciplinary Graduate Program in Immunology and {dagger}Department of Microbiology, University of Iowa, Iowa City

@ To whom correspondence should be addressed. E-mail: john-harty{at}uiowa.edu.


  Abstract

The immune system has adapted to affect different mechanisms to combat the multitude of potential pathogens in our environment. In particular, CD8 T cells are participants in the immune response to intracellular pathogens, which include viruses, certain types of bacteria, and protozoa. Classified as members of the adaptive immune system, antigen-specific CD8 T cells, which have been activated, eventually form a pool of memory CD8 T cells, which has an enhanced ability to protect against subsequent infections. The generation of antigen-specific CD8 T cells, therefore, is a potential approach in the design of vaccines, especially for those pathogens in which the humoral response is insufficient to protect the host.

Key Words: vaccination • adaptive immunity • acute infection




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