Accuri C6 Flow Cytometer System
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Published online before print October 4, 2005
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© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.0205073

Received for publication February 4, 2005.
Revised July 14, 2005.
Accepted for publication July 15, 2005.

Article

Decreased clearance of Pseudomonas aeruginosa from airways of mice deficient in lysozyme M

Alexander M. Cole *@, Dharma R. Thapa {dagger}, Victoria Gabayan {dagger}, Hsiang-I Liao {dagger}, Lide Liu {dagger}, and Tomas Ganz {dagger}@

*Department of Molecular Biology and Microbiology, Biomolecular Science Center, University of Central Florida, Orlando; and {dagger}Department of Medicine, Division of Pulmonary and Critical Care Medicine and the Will Rogers Institute Pulmonary Research Laboratory, David Geffen School of Medicine at University of California Los Angeles

@ To whom correspondence should be addressed. E-mail: tganz{at}mednet.ucla.edu.


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Abstract

Lysozyme is a ubiquitous and abundant, cationic, antimicrobial polypeptide of leukocytes and epithelia, but its biological function in host defense is largely unexplored. To ascertain the role of lysozyme during bacterial infection of murine airways, we exposed the airways of lysozyme M-deficient (lys M-/-) mice to the pulmonary pathogen Pseudomonas aeruginosa and examined the host’s response to infection. Despite partial compensation as a result of the appearance of lysozyme P in the infected airways of lys M-/- mice, these lys M-/- mice showed decreased clearance of P. aeruginosa compared with their lys M+/- or lys M+/+ littermates. Lysozyme contributes to optimal clearance of P. aeruginosa from the murine airways.

Key Words: knockout • bacteria




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