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Published online before print August 4, 2005

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© by The Society for Leukocyte Biology
Journal of Leukocyte Biology, doi:10.1189/jlb.0105007

Received for publication January 7, 2005.
Revised June 19, 2005.
Accepted for publication June 21, 2005.

Article

In vivo rescue of defective memory CD8⁺ T cells by cognate helper T cells

Department of Microbiology, University of Tennessee, Knoxville

^@ To whom correspondence should be addressed. E-mail: udayk{at}utk.edu.

	Abstract

The magnitude and efficacy of CD8⁺ T cell memory may notably regress, especially if immune induction occurs in the absence of adequate CD4⁺ help. This report demonstrates that this CD8⁺ memory malfunction could be remedied if a source of cognate antigen-recognizing helper cells were provided during recall. The inability of adoptive transfer of memory SIINFEKL-specific CD8 cells to reject tumors was overcome if recipients were primed for ovalbumin-specific helper cell responses. Additionally, animals primed for a SIINFEKL-specific memory response and incapable of rejecting the tumor could regain protective immunity if given helper cells. This pattern of CD8⁺ T cell functional rescue or reprogramming by helper cell transfer was replicated using a Herpes simplex virus antiviral immunity system. Our results could mean that therapeutic vaccine approaches could be designed to compensate situations that have defective CD8⁺ T cell function.

Key Words: vaccine • HSV

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